ReviewCurrent opinion in neurobiology2021
Neural circuit function redundancy in brain disorders.
Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Genetic frontotemporal degeneration across the lifespan? A critical appraisal of the neurodevelopmental hypothesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Relapse in alcohol dependence is characterized by disrupted modular brain network organization.European archives of psychiatry and clinical neuroscience · 2026Article
- Whole-Brain Neural Connectivity to Cholinergic Neurons in the Lower Thoracic Intermediolateral Column.CNS neuroscience & therapeutics · 2026Article
- Memetics and the Parallel Architecture.Topics in cognitive science · 2025Article
- Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.Nature communications · 2025Article
- Towards realistic simulation of disease progression in the visual cortex with CNNs.Scientific reports · 2025Article
- Article
- Brain-Inspired Architecture for Spiking Neural Networks.Biomimetics (Basel, Switzerland) · 2024Article
- Improved cognition after rifaximin treatment is associated with changes in intra- and inter-brain network functional connectivity.Journal of translational medicine · 2024Article
- Virtual lesions in MEG reveal increasing vulnerability of the language network from early childhood through adolescence.Nature communications · 2023Article
- Intrinsic neural diversity quenches the dynamic volatility of neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary dynamics of mushroom body Kenyon cell types in hymenopteran brains from multifunctional type to functionally specialized types.Science advances · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Design for Robustness: Bio-Inspired Perspectives in Structural Engineering.Biomimetics (Basel, Switzerland) · 2023Article
- Simulation of neuroplasticity in a CNN-basedFrontiers in computational neuroscience · 2023Article
- Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.