Evidence map›Paper›PMID 34418445›Full record

ReviewJournal of neuroscience methods2021

Synthetic nanosensors for imaging neuromodulators.

Jackson Travis Del Bonis-O'Donnell, Jaewan Mun, Kristen Delevich, Markita P Landry

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jackson Travis Del Bonis-O'DonnellDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.
Jaewan MunDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.
Kristen DelevichDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. Electronic address: kristen.delevich@wsu.edu.
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences (QB3), Berkeley, CA, USA; Chan-Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: landry@berkeley.edu.
University of California, Berkeley · USQB3 · USWashington State University · US

Funding

The Function of Neural Activity in Developing RetinaR01EY013528 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Marla Feller · 2002 to 2026
$8.1M
Single-Molecule Imaging of Biological Trauma:Cytokine-Based Intracellular CommunicationR35GM128922 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDRY, MARKITA · 2019 to 2023
$2.0M
Novel optical probe for dopamine release in neural circuitsR21EY029405 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FELLER, MARLA, LANDRY, MARKITA · 2018 to 2019
$428k
Imaging presynaptic correlates of cocaine locomotor sensitization with near infrared catecholamine nanosensorsR03DA052810 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDRY, MARKITA · 2021 to 2021
$223k
NEI NIH HHS R01 EY013528NEI NIH HHS R21 EY029405NIGMS NIH HHS R35 GM128922
6 · The paper itself

Abstract

Neuromodulation plays a critical role in regulating brain function and its dysregulation is implicated in the pathogenesis of numerous neurological and psychiatric disorders. However, only in the last few years have optical tools become available to probe the spatial and temporal profiles of neuromodulator signaling, including dopamine, with the requisite resolution to uncover mechanisms of neuromodulation. In this review, we summarize the current state of synthetic nanomaterial-based optical nanosensors for monitoring neurotransmission with high spatial and temporal resolution. Specifically, we highlight how synthetic nanosensors can elucidate the spatial distribution of neuromodulator release sites and report the temporal dynamics and spatial diffusion of neuromodulator release. Next, we outline advantages and limitations of currently available nanosensors and their recent application to imaging endogenous dopamine release in brain tissue. Finally, we discuss strategies to improve nanosensors for in vivo use, with implications for translational applications.

Indexed as

DopamineNeurotransmitter AgentsBrainHumansSignal TransductionSynaptic TransmissionDopamineNeurotransmitter AgentsDopamineNear infrared imagingNeuromodulationSingle-walled carbon nanotubes (SWNTs)

Identifiers

PMID34418445
PMCPMC12017774
OpenAlexW3195606215

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.