Evidence map›Paper›PMID 34420064›Full record

Trial reportJournal of neurology2022

Obstructive sleep apnoea in women with idiopathic intracranial hypertension: a sub-study of the idiopathic intracranial hypertension weight randomised controlled trial (IIH: WT).

Andreas Yiangou, James L Mitchell, Matthew Nicholls, Yu Jeat Chong, Vivek Vijay, Benjamin R Wakerley, Gareth G Lavery, Abd A Tahrani, Susan P Mollan, Alexandra J Sinclair

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02124486 (A Randomised Controlled Trial of Bariatric Surgery Versus a Community Weight Loss Programme for the Sustained Treatment of Idiopathic Intracranial Hypertension), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02124486 naunknown statusnot on this map

A Randomised Controlled Trial of Bariatric Surgery Versus a Community Weight Loss Programme for the Sustained Treatment of Idiopathic Intracranial Hypertension: the IIH:WT Trial

TypeinterventionalSponsorUniversity of BirminghamRan2014 to 2022Enrolled90ConditionsIdiopathic Intracranial HypertensionArmsBariatric surgery, Dietetic intervention
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Clinical characteristics and outcomes of non-obese patients with idiopathic intracranial hypertension: a retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  19. Sleep and eye disease: A review.Clinical & experimental ophthalmology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Andreas YiangouMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0001-8905-5734
James L MitchellMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Matthew NichollsMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Yu Jeat ChongBirmingham Neuro-Ophthalmology, Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, B15 2TH, UK.
Vivek VijayMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0002-6843-5532
Benjamin R WakerleyDepartment of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.ORCID http://orcid.org/0000-0003-1016-5207
Gareth G LaveryMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0001-5794-748X
Abd A TahraniMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0001-9037-1937
Susan P MollanBirmingham Neuro-Ophthalmology, Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, B15 2TH, UK.ORCID http://orcid.org/0000-0002-6314-4437
Alexandra J SinclairMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. a.b.sinclair@bham.ac.uk.ORCID http://orcid.org/0000-0003-2777-5132
University Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GB

Funding

Department of Health NIHR-CS-011-028Medical Research Council MR/K015184/1National Institute for Health Research NIHR-CS-011-028National Institute for Health Research NIHR-CS-2013-13-029Sir Jules Thorn Charitable Trust Award for Biomedical ScienceWellcome TrustWellcome Trust 104612/Z/14/Z
6 · The paper itself

Abstract

objectiveObesity is a risk factor for idiopathic intracranial hypertension (IIH) and obstructive sleep apnoea (OSA). We aimed to determine the prevalence of OSA in IIH and evaluate the diagnostic performance of OSA screening tools in IIH. Additionally, we evaluated the relationship between weight loss, OSA and IIH over 12 months.

methodsA sub-study of a multi-centre, randomised controlled parallel group trial comparing the impact of bariatric surgery vs. community weight management intervention (CWI) on IIH-related outcomes over 12 months (IIH:WT). OSA was assessed using home-based polygraphy (ApneaLink Air, ResMed) at baseline and 12 months. OSA was defined as an apnoea-hypopnoea index (AHI) ≥ 15 or ≥ 5 with excessive daytime sleepiness (Epworth Sleepiness Scale ≥11 ).

resultsOf the 66 women in the IIH: WT trial, 46 were included in the OSA sub-study. OSA prevalence was 47% (n = 19). The STOP-BANG had the highest sensitivity (84%) compared to the Epworth Sleepiness Scale (69%) and Berlin (68%) to detect OSA. Bariatric surgery resulted in greater reductions in AHI vs. CWI (median [95%CI] AHI reduction of  - 2.8 [ - 11.9, 0.7], p = 0.017). Over 12 months there was a positive association between changes in papilloedema and AHI (r = 0.543, p = 0.045), despite adjustment for changes in the body mass index (R

conclusionOSA is common in IIH and the STOP-BANG questionnaire was the most sensitive screening tool. Bariatric surgery improved OSA in patients with IIH. The improvement in AHI was associated with improvement in papilloedema independent of weight loss. Whether OSA treatment has beneficial impact on papilloedema warrants further evaluation. TRIAL REGISTRATION NUMBER: IIH: WT is registered as ISRCTN40152829 and on ClinicalTrials.gov as NCT02124486 (28/04/2014).

Indexed as

Bariatric SurgeryPseudotumor CerebriSleep Apnea, ObstructiveBody Mass IndexFemaleHumansWeight LossBariatric surgeryIdiopathic intracranial hypertensionObstructive sleep apnoeaPapilloedemaScreening

Identifiers

PMID34420064
PMCPMC8940816
OpenAlexW3186847141

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.