SynthesisFrontiers in psychiatry2021
Significant Increase in Depression in Women With Primary Dysmenorrhea: A Systematic Review and Cumulative Analysis.
Synthesis in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The genetics of primary dysmenorrhoea: a systematic review.Reproduction & fertility · 2026Pooled it
- Depression, Nutritional Status, and Substance P/NK-1R Biomarkers in Dysmenorrhea: A Randomized Crossover Trial.Depression and anxiety · 2026Trial
- Effects of chamomile and -theanine beverage on menstrual pain, menstrual symptoms, mood, and sleep quality in young women experiencing primary dysmenorrhea: A randomized, double-blind, placebo-controlled study.Journal of food and drug analysis · 2025Trial
- The balancing act of app creation: Navigating the user-centred design of an industry-developed app for adolescents with menstrual pain.Internet interventions · 2026Article
- Particular promotion of the intrauterine system to "vulnerable" adolescents: a qualitative exploration of hormonal contraceptive prescription practices.Reproductive health · 2026Article
- Dysmenorrhea patients' experience with work productivity impact and treatment in Japan.BMC women's health · 2026Article
- A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviors.iScience · 2026Article
- Effect of Primary Dysmenorrhea on the Mental Health Quality of Medical Students in Saudi Arabia.Cureus · 2026Article
- Prevalence, severity and correlates of dysmenorrhea among postpartum women in Western Kenya: A cross-sectional study.PLOS global public health · 2026Article
- Clinical efficacy and neural mechanisms of Tuina for primary dysmenorrhea with cold congestion and blood stasis pattern: a protocol for a randomized controlled fMRI trial.Frontiers in medicine · 2026Article
- Impact of Dysmenorrhea Severity on Mental Wellbeing and Quality of Life Among Saudi Women: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- The association between various menstrual disorders and well-being was mediated by anxiety: a cross-sectional study.BMC women's health · 2025Article
- Erythema ab igne-A Potential Cutaneous Marker of Chronic Heat Use in Patients with Endometriosis: A Narrative Literature Review and a Case Report.Life (Basel, Switzerland) · 2025Article
- Effect of eye movement desensitization and reprocessing on intensity of primary dysmenorrhea: a randomized controlled trial.Discover mental health · 2025Article
- Use of systemic hormonal contraception and risk of depression: a registry-based study from Finland.European journal of epidemiology · 2025Article
- Article
- Beyond the Cycle: Investigating the Relationship Between Menstrual Hygiene Factors, Family Economic Stability, and Depression Among Adolescent Girls in Uganda-A 24 Month Mixed-Effects Regression Analysis of the Suubi4Her Trial.International journal of women's health · 2025Article
- Immediate analgesic effect of acupuncture for acute primary dysmenorrhea: protocol of a randomized controlled trial.Frontiers in medicine · 2025Article
- Current Status of Depression in Patients with Endometriosis and Rheumatoid Arthritis.Actas espanolas de psiquiatria · 2025Article
- Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study.Briefings in bioinformatics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women with primary dysmenorrhea are vulnerable to develop a depressive disorder, which is a common form of psycho-disturbance. However, clinical findings are inconsistent across studies, and the evidence has not been previously synthesized. This study aims to investigate whether primary dysmenorrhea is associated with a higher risk of depression via a cumulative analysis. Four electronic databases were systematically searched for the eligible studies. The combined effect was assessed by analyzing the relative risk (RR) and standard mean differences (SMD) with a 95% confidence interval (CI). This cumulative analysis was registered on the PROSPERO (ID: CRD42020169601). Of 972 publications, a total of 10 studies involving 4,691 participants were included. Pooled results from six included studies showed that primary dysmenorrhea was associated with a significant depressive disorder (
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.