Evidence map›Paper›PMID 34422900›Full record

ArticleFrontiers in molecular biosciences2021

Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway.

Caijuan Huan, Wangting Xu, Yaru Liu, Kexin Ruan, Yueli Shi, Hongqiang Cheng, Xue Zhang, Yuehai Ke, Jianying Zhou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Inclusivity in Research Matters: Variants inAmerican journal of respiratory and critical care medicine · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Caijuan HuanDepartment of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wangting XuDepartment of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yaru LiuDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Kexin RuanDepartment of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yueli ShiThe Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Hongqiang ChengDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Xue ZhangDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Yuehai KeDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Jianying ZhouDepartment of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing unremitting extracellular matrix deposition. Transforming growth factor-β (TGF-β) superfamily involves bone morphogenetic proteins (BMPs) and TGF-β, and the balance between the activation of TGF-β-dependent SMADs (Smad2/3) and BMP-dependent SMADs (Smad1/5/8) is essential for fibrosis process.

Indexed as

BMP antagonistsfibroblastgremlin2IPF (idiopathic pulmonary fibrosis)P-smad1

Identifiers

PMID34422900
PMCPMC8377751
OpenAlexW3173985084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.