Evidence map›Paper›PMID 34424600›Full record

ArticleCancer science2021

LncRNA AC020978 facilitates non-small cell lung cancer progression by interacting with malate dehydrogenase 2 and activating the AKT pathway.

Fei Xu, Qian Hua, Aimi Zhang, Zhang Di, Yining Wang, Li Zhao, Hao Yang, Jianjun Liu, Gang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Long noncoding RNAs regulating enzymatic reactions in cancer.Experimental & molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fei XuDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0003-3071-3186
Qian HuaDepartment of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Aimi ZhangDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Zhang DiDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yining WangDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Li ZhaoDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Hao YangShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Jianjun LiuDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Gang HuangDepartment of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Renji Hospital · CNShanghai University of Medicine and Health Sciences · CNSoochow University · CN

Funding

National Natural Science Foundation of China 81530053National Natural Science Foundation of China 81830052National Natural Science Foundation of China 81903065Shanghai Key Laboratory of Molecular Imaging 18DZ2260400Shanghai Municipal Education Commission (Class II Plateau Disciplinary ConstructionProgram of Medical Technology of SUMHS, 2018-2020)
6 · The paper itself

Abstract

Long non-coding RNA AC020978 (lncRNA AC020978) is an oncogenic regulator of non-small cell lung cancer (NSCLC). However, the function of AC020978 in regulating NSCLC metastasis and the potential molecular mechanism remains largely unknown. In this study, we evaluated the expression levels of AC020978 in a series of NSCLC tissues using FISH assays and found that higher AC020978 expression levels were closely associated with metastasis and unfavorable prognosis. Functional studies showed that AC020978 promoted NSCLC migration and invasion both in vitro and in vivo. Further investigation demonstrated that AC020978 interacted with malate dehydrogenase 2 (MDH2) and maintained MDH2 stability. Knockdown of MDH2 weakened the facilitating effect on cell metastasis and 2-hydroxyglutarate (2-HG) metabolism in AC020978-overexpressed NSCLC cells. RNA sequencing, bioinformatic analysis, and western blotting revealed that AC020978 was associated with the AKT signaling pathway. Taken together, our findings revealed that AC020978 might serve as a prognostic biomarker and activate the AKT pathway by stabilizing MDH2, leading to metastasis and progression of NSCLC.

Indexed as

Disease ProgressionA549 CellsAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementFemaleGlutaratesHumansIn Situ Hybridization, FluorescenceLung NeoplasmsMalate DehydrogenaseMaleMiceMice, Inbred BALB CMice, Nudealpha-hydroxyglutarateGlutaratesMalate DehydrogenaseMDH2 protein, humanProto-Oncogene Proteins c-aktRNA, Long NoncodingAKTlncRNAMDH2metastasisNSCLC

Identifiers

PMID34424600
PMCPMC8586664
OpenAlexW3193658486

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.