ArticlePLoS biology2021
Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 121 citations in OpenAlex.
- A built-in brake for plant immunity: Resistance (R) protein-mediated immunity is fine-tuned byScience advances · 2026Article
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026Review
- A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome.Science advances · 2026Article
- A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.Science advances · 2026Article
- ESCRT: A Cellular Nexus of Plant Immunity and Pathogen Counter-Strategies.Molecular plant pathology · 2026Review
- TOM1 family proteins: from cargo sorting to immune dysregulation and cancer.Cell communication and signaling : CCS · 2026Review
- Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026Review
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The diverse roles of host membranes in plant-microbe interactions.PLoS pathogens · 2026Article
- Pathogen effector tactics to suppress plant endomembrane system.Frontiers in plant science · 2026Review
- Gpa2 detects the potato cyst nematode effector GpRBP-1 in the cytoplasm but requires a balanced nucleocytoplasmic distribution to trigger cell death.Journal of experimental botany · 2025Article
- Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector.PLoS genetics · 2025Article
- The SUbventral-Gland Regulator (SUGR-1) of nematode virulence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A dual transcriptome analysis reveals accession-specific resistance responses inFrontiers in plant science · 2025Article
- Advances in understanding the interaction betweenPlant signaling & behavior · 2024Review
- A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity.Science advances · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
- NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages.The Plant cell · 2024Article
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Authors and funding
16 authors at 4 institutions in 6 countries.
Funding
Abstract
In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can form receptor networks to confer hypersensitive cell death and innate immunity. One class of NLRs, known as NLR required for cell death (NRCs), are central nodes in a complex network that protects against multiple pathogens and comprises up to half of the NLRome of solanaceous plants. Given the prevalence of this NLR network, we hypothesised that pathogens convergently evolved to secrete effectors that target NRC activities. To test this, we screened a library of 165 bacterial, oomycete, nematode, and aphid effectors for their capacity to suppress the cell death response triggered by the NRC-dependent disease resistance proteins Prf and Rpi-blb2. Among 5 of the identified suppressors, 1 cyst nematode protein and 1 oomycete protein suppress the activity of autoimmune mutants of NRC2 and NRC3, but not NRC4, indicating that they specifically counteract a subset of NRC proteins independently of their sensor NLR partners. Whereas the cyst nematode effector SPRYSEC15 binds the nucleotide-binding domain of NRC2 and NRC3, the oomycete effector AVRcap1b suppresses the response of these NRCs via the membrane trafficking-associated protein NbTOL9a (Target of Myb 1-like protein 9a). We conclude that plant pathogens have evolved to counteract central nodes of the NRC immune receptor network through different mechanisms. Coevolution with pathogen effectors may have driven NRC diversification into functionally redundant nodes in a massively expanded NLR network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.