ArticlePloS one2021
Pain relief associated with decreased oxyhemoglobin level in left dorsolateral prefrontal cortex.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Systematic review: pain, cognition, and cardioprotection-unpacking oxytocin's contributions in a sport context.Frontiers in physiology · 2024Pooled it
- Sweet taste stimulation reduced pain ratings associated with increased blood flow in the right dorsolateral prefrontal cortex: A pilot study using NIRS.Biophysics and physicobiology · 2026Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
- Near-infrared spectroscopic study of blood flow changes in the dorsolateral prefrontal cortex during pain relief by odor stimulation.Biophysics and physicobiology · 2025Article
- Article
- Brain activity in response to food images in patients with irritable bowel syndrome and functional dyspepsia.Journal of gastroenterology · 2023Article
- Revisiting oxytocin generation in keratinocytes.Biophysics and physicobiology · 2023Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Dorsolateral prefrontal cortex sensing analgesia.Biophysics and physicobiology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain in the elbow, shoulder, knee, lower back, and various other joints is relieved by adhesion of pyramidal thorn patches. To elucidate the pain relief mechanism induced by the patches, we established a quantitative method for estimating the pain reduction and investigated the brain regions that change in association with pain relief. We first attempted to quantify the pain relief using transcutaneous electric stimulation (TCES) and a visual analog scale (VAS), and then applied near-infrared spectroscopy (NIRS) to the prefrontal cortex, including the dorsolateral prefrontal cortex (DLPFC) and the orbitofrontal cortex (OFC). We also examined the salivary oxytocin levels, which are thought to reflect oxytocin secretion levels from the posterior pituitary in the brain. Application of pyramidal thorn patches to pain regions decreased the pain degree estimated using TCES and VAS. Oxyhemoglobin levels were likely to be decreased in the left DLPFC on the basis of NIRS measurements during patch treatment, suggesting that the left DLPFC is involved in pain relief. On the other hand, the salivary oxytocin levels varied widely. A potential reason for the varying salivary oxytocin levels is its utilization in the pain region as an analgesic agent. Our results suggest that the left DLPFC will become a target brain region for pain therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.