Evidence map›Paper›PMID 34425916›Full record

ArticleBiomarker research2021

Circulating MicroRNAs predict glycemic improvement and response to a behavioral intervention.

Elena Flowers, Isabel Elaine Allen, Alka M Kanaya, Bradley E Aouizerat

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarker research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01024816 (Practicing Restorative Yoga or Stretching for the Metabolic Syndrome), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01024816 nacompletednot on this map

Practicing Restorative Yoga or Stretching for the Metabolic Syndrome

TypeinterventionalSponsorUniversity of California, San FranciscoRan2009 to 2013Enrolled180ConditionsMetabolic SyndromeArmsRestorative yoga, Stretching
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Temporal dysregulation ofResearch square · 2025
    Article
  6. Article
  7. Review
  8. MicroRNAs Associated With Incident Diabetes in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2023
    Article
  9. Glycemia-Induced miRNA Changes: A Review.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elena FlowersDepartment of Physiological Nursing, University of California, San Francisco, 2 Koret Way, #605L, CA, 94143-0610, San Francisco, USA. elena.flowers@ucsf.edu.ORCID http://orcid.org/0000-0002-7054-7533
Isabel Elaine AllenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Alka M KanayaDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0002-8903-1457
Bradley E AouizeratBluestone Center for Clinical Research, New York University, New York, USA.ORCID http://orcid.org/0000-0002-6047-9397
University of California, San Francisco · USCenter for Clinical Research (United States) · US

Funding

NCATS NIH HHS KL2 TR000143NCATS NIH HHS KL2TR000143NCCIH NIH HHS R01 AT004569NCCIH NIH HHS R01AT004569NHLBI NIH HHS 2K24HL112827NHLBI NIH HHS K24 HL112827NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R21 DK117346NIDDK NIH HHS R21DK117346
6 · The paper itself

Abstract

backgroundMicroRNAs may be important regulators of risk for type 2 diabetes. The purpose of this longitudinal observational study was to assess whether circulating microRNAs predicted improvements in fasting blood glucose, a major risk factor for type 2 diabetes, over 12 months.

methodsThe study included participants (n = 82) from a previously completed trial that tested the effect of restorative yoga on individuals with prediabetes. Circulating microRNAs were measured using a flow cytometry miRNA assay. Linear models were used to determine the optimal sets of microRNA predictors overall and by intervention group.

resultsSubsets of microRNAs were significant predictors of final fasting blood glucose after 12-months (R

conclusionsCirculating microRNAs are significant predictors of fasting blood glucose in individuals with prediabetes. Among the identified microRNAs, several have previously been associated with risk for type 2 diabetes. This is one of the first studies to use a longitudinal design to assess whether microRNAs predict changes in fasting blood glucose over time. Further exploration of the function of the microRNAs included in these models may provide new insights about the complex etiology of type 2 diabetes and responses to behavioral risk reduction interventions.

trial registrationThis study was a secondary analysis of a previously completed clinical trial that is registered at clinicaltrials.gov (NCT01024816) on December 3, 2009.

Indexed as

BiomarkerDiabetesFasting blood glucosemicroRNAYoga

Identifiers

PMID34425916
PMCPMC8383422
OpenAlexW3193866118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.