ReviewTrends in endocrinology and metabolism: TEM2021
Reframing anorexia nervosa as a metabo-psychiatric disorder.
Review in Trends in endocrinology and metabolism: TEM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- 2025 Update to the Female Athlete Triad Coalition Consensus Statement Part 2: Clinical Guidelines for Screening, Diagnosis, Treatment, and Return to Play for Adolescents and Adults.Sports medicine (Auckland, N.Z.) · 2026Guideline
- Anorexia nervosa and microbiota: systematic review and critical appraisal.Eating and weight disorders : EWD · 2023Pooled it
- Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial.The British journal of nutrition · 2026Trial
- Famine, plague, and slaughters: The fleeing famine hypothesis of anorexia nervosa reconsidered.Psychological review · 2026Article
- Anchoring Anorexia Nervosa Within Biological Psychiatry Through Metabolic Pathways.Biological psychiatry global open science · 2026Article
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- From gut to brain: effects of fecal microbiota transplants from humans to rats on hippocampal gene regulation - a study on anorexia nervosa.Translational psychiatry · 2026Article
- Increasing visibility of the neurobiology of eating disorders in youth - a commentary on Hagan et al. (2025).Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The role of LEAP2 on cognitive impulsivity after refeeding: evidence from a preclinical study in female mice and from patients with anorexia nervosa.Translational psychiatry · 2026Article
- GLP-1 is associated with perfectionism in Swedish women with anorexia nervosa, independent of BMI.Eating and weight disorders : EWD · 2026Article
- Exploring the Genetic Overlap Between Metabolic Traits and Anorexia Nervosa.Biological psychiatry global open science · 2026Article
- Impact of acute anorexia nervosa and of short-/long-term recovery after refeeding on the hormonal profiles of activin A, GDF-15 and follistatins.Molecular psychiatry · 2026Article
- Anorexia nervosa: 150 years of critical theory.Journal of eating disorders · 2026Review
- Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial.Nature communications · 2026Article
- The Norwegian Microbiota Study in Anorexia Nervosa (NORMA): Integrating a clinical trial with preclinical experiments-A study protocol.PloS one · 2026Article
- Metabolic regulation of synaptic plasticity in anorexia nervosa.Frontiers in synaptic neuroscience · 2026Review
- Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice.Gut microbes · 2025Article
- Drivers of hypoglycaemia in anorexia nervosa: Clinical severity, BMI, and illness duration.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Anorexia nervosa (AN) is a serious and often fatal illness. Despite decades of research, investigators have failed to adequately advance our understanding of the biological aspects of AN that could inform the development of effective interventions. Genome-wide association studies are revealing the important role of metabolic factors in AN, and studies of the gastrointestinal tract are shedding light on disruptions in enteric microbial communities and anomalies in gut morphology. In this opinion piece, we review the state of the science through the lens of the clinical presentation of illness. We project how the integration of rigorous science in genomics and microbiology, in collaboration with experienced clinicians, has the potential to markedly enhance treatment outcome via precision interventions.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.