Evidence map›Paper›PMID 34429319›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2021

Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model.

Jill P Smith, Hong Cao, Wenqiang Chen, Bhaskar Kallakury, Teresa Phillips, Lynda Sutton, Allen Cato

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jill P SmithDepartment of Medicine, Georgetown University, Washington D.C. jps261@georgetown.edu.
Hong CaoDepartment of Medicine, Georgetown University, Washington D.C.
Wenqiang ChenDepartment of Medicine, Georgetown University, Washington D.C.
Bhaskar KallakuryDepartment of Pathology, Georgetown University, Washington D.C.
Teresa PhillipsCancer Advances, Inc. Durham, North Carolina.
Lynda SuttonCancer Advances, Inc. Durham, North Carolina.
Allen CatoCancer Advances, Inc. Durham, North Carolina.
Georgetown University · USHealth Advances (United States) · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

The incidence of pancreatic cancer is increasing significantly and will soon become the second leading cause of cancer-related deaths in the United States. We have previously shown that the gastrointestinal peptide gastrin, which is only expressed in the fetal pancreas and not in the adult pancreas, is activated during pancreatic carcinogenesis where it stimulates growth in an autocrine fashion. In this investigation, we used transgenic LSL-Kras

Indexed as

AnimalsAntibodiesCancer VaccinesCarcinogenesisDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicPancreasPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Tumor MicroenvironmentVaccinationAntibodiesCancer VaccinesHras protein, mouseProto-Oncogene Proteins p21(ras)

Identifiers

PMID34429319
PMCPMC8525505
OpenAlexW3193979350

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.