Evidence map›Paper›PMID 34433040›Full record

ArticleCell reports2021

Dual role for CXCL12 signaling in semilunar valve development.

Liam A Ridge, Dania Kewbank, Dagmar Schütz, Ralf Stumm, Peter J Scambler, Sarah Ivins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Liam A RidgeDevelopmental Biology of Birth Defects, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Dania KewbankDevelopmental Biology of Birth Defects, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Dagmar SchützInstitute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena 07747, Germany.
Ralf StummInstitute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena 07747, Germany.
Peter J ScamblerDevelopmental Biology of Birth Defects, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Sarah IvinsDevelopmental Biology of Birth Defects, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: s.ivins@ucl.ac.uk.
Great Ormond Street Hospital · GBUniversity College London · GBFriedrich Schiller University Jena · DEJena University Hospital · DE

Funding

British Heart Foundation PG/14/35/30837British Heart Foundation RG/15/14/31880
6 · The paper itself

Abstract

Cxcl12-null embryos have dysplastic, misaligned, and hyperplastic semilunar valves (SLVs). In this study, we show that CXCL12 signaling via its receptor CXCR4 fulfills distinct roles at different stages of SLV development, acting initially as a guidance cue to pattern cellular distribution within the valve primordia during the endocardial-to-mesenchymal transition (endoMT) phase and later regulating mesenchymal cell proliferation during SLV remodeling. Transient, anteriorly localized puncta of internalized CXCR4 are observed in cells undergoing endoMT. In vitro, CXCR4

Indexed as

AnimalsCell MovementCell ProliferationChemokine CXCL12MiceMice, Inbred C57BLMorphogenesisOrganogenesisPhosphatidylinositol 3-KinasesReceptors, CXCRReceptors, CXCR4Signal TransductionChemokine CXCL12Cmkor1 protein, mouseCxcl12 protein, mouseCXCR4 protein, mousePhosphatidylinositol 3-KinasesReceptors, CXCRReceptors, CXCR4cell migrationCXCL12CXCR4CXCR7outflow tractsemilunar valvesvalve dysplasiavalve hyperplasiavalve primordia

Identifiers

PMID34433040
PMCPMC8411116
OpenAlexW3195556888

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.