Evidence map›Paper›PMID 34434653›Full record

ArticlePeerJ2021

N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats.

Yitong Pan, Shuna Yu, Jianxin Wang, Wanzhen Li, Huiting Li, Chen Bai, Yaxin Sheng, Ming Li, Chenchen Wang, Jiao Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yitong Pan *Department of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Shuna Yu *Department of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Jianxin WangDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Wanzhen LiDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Huiting LiDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Chen BaiDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Yaxin ShengDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Ming LiDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Chenchen WangDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Jiao LiuDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Peitong Xie2018 Grade 2 Glasses, Anaesthesiology Specialty, Weifang Medical University, Weifang, Shandong, China.
Can WangDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Jiying JiangDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.
Jianguo LiDepartment of Anatomy, Weifang Medical University, Weifang, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the changes of TLR4/NLRP3 signal during hepatic ischemia-reperfusion injury (HIRI) and to verify whether N-acetyl-L-tryptophan (L-NAT) protected hepatocytes by regulating the activation of TLR4/NLRP3 signal. We have established the rat HIRI model and H

Indexed as

Hepatic ischemia-reperfusion injuryL-NATNLRP3Pyroptosis

Identifiers

PMID34434653
PMCPMC8362669

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.