Evidence map›Paper›PMID 34435757›Full record

ArticleClinical and translational allergy2021

Persistent human bocavirus 1 infection and tonsillar immune responses.

Lotta E Ivaska, Antti Silvoniemi, Oscar Palomares, Riitta Turunen, Matti Waris, Emilia Mikola, Tuomo Puhakka, Maria Söderlund-Venermo, Mübeccel Akdis, Cezmi A Akdis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Lotta E IvaskaDepartment of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-0169-2681
Antti SilvoniemiDepartment of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.
Oscar PalomaresSwiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.
Riitta TurunenDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Matti WarisClinical Microbiology, Turku University Hospital, Turku, Finland.
Emilia MikolaDepartment of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.
Tuomo PuhakkaDepartment of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland.
Maria Söderlund-VenermoDepartment of Virology, University of Helsinki, Helsinki, Finland.
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.
Tuomas JarttiDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
University of Turku · FIUniversity of Helsinki · FIUniversity of Zurich · CHUniversidad Complutense de Madrid · ES

Funding

Allergy Research FoundationFinnish Cultural FoundationFoundation for Pediatric ResearchPaulo FoundationThe Finnish ORL-HNS FoundationThe Sigrid Juselius Foundation
6 · The paper itself

Abstract

backgroundPersistent human bocavirus 1 (HBoV1) infection is a common finding in patients suffering from chronic tonsillar disease. However, the associations between HBoV1 infection and specific immune reactions are not completely known. We aimed to compare in vivo expression of T-cell cytokines, transcription factors, and type I/III interferons in human tonsils between HBoV1-positive and -negative tonsillectomy patients.

methodsTonsil tissue samples, nasopharyngeal aspirate (NPA), and serum samples were obtained from 143 immunocompetent adult and child tonsillectomy patients. HBoV1 and 14 other respiratory viruses were detected in NPAs and tonsil tissues by polymerase chain reaction (PCR). Serology and semi-quantitative PCR were used for diagnosing HBoV1 infections. Expression of 14 cytokines and transcription factors (IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2, Tbet) was analyzed by quantitative reverse-transcription (RT)-PCR in tonsil tissues.

resultsHBoV1 was detected by PCR in NPA and tonsils from 25 (17%) study patients. Serology results indicated prior nonacute infections in 81% of cases. Tonsillar cytokine responses were affected by HBoV1 infection. The suppression of two transcription factors, RORC2 and FOXP3, was associated with HBoV1 infection (p < 0.05). Furthermore, intratonsillar HBoV1-DNA loads correlated negatively with IFN-λ family cytokines and IL-13.

conclusionsOur study shows distinctively decreased T-helper

Indexed as

cytokineforkheadbox protein 3FOXP3human bocavirusRAR-related orphan receptor C 2RORC2T-helper17tonsiltranscription factorT-regulatory

Identifiers

PMID34435757
PMCPMC8459348
OpenAlexW3194925819

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.