Evidence map›Paper›PMID 34438715›Full record

ArticleAnimals : an open access journal from MDPI2021

Genome-Wide Association Study Identifies Candidate Genes Associated with Feet and Leg Conformation Traits in Chinese Holstein Cattle.

Ismail Mohamed Abdalla, Xubin Lu, Mudasir Nazar, Abdelaziz Adam Idriss Arbab, Tianle Xu, Mohammed Husien Yousif, Yongjiang Mao, Zhangping Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ismail Mohamed AbdallaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xubin LuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0001-6286-1517
Mudasir NazarCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Abdelaziz Adam Idriss ArbabCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Tianle XuJoint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-8479-3372
Mohammed Husien YousifFaculty of Animal Production, West Kordufan University, Alnuhud City 12942, Sudan.
Yongjiang MaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Zhangping YangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-5479-8447

Funding

National Natural Science Foundation of China 31872324the Earmarked Fund for Jiangsu Agricultural Industry Technology System (JATS [2019]446)the Postgraduate Research & Practice Innovation Program of Jiangsu Province (XKYCX20_026)
6 · The paper itself

Abstract

Feet and leg conformation traits are considered one of the most important economical traits in dairy cattle and have a great impact on the profitability of milk production. Therefore, identifying the single nucleotide polymorphisms (SNPs), genes and pathways analysis associated with these traits might contribute to the genomic selection and long-term plan selection for dairy cattle. We conducted genome-wide association studies (GWASs) using the fixed and random model circulating probability unification (FarmCPU) method to identify SNPs associated with bone quality, heel depth, rear leg side view and rear leg rear view of Chinese Holstein cows. Phenotypic measurements were collected from 1000 individuals of Chinese Holstein cattle and the GeneSeek Genomic Profiler Bovine 100 K SNP chip was utilized for individual genotyping. After quality control, 984 individual cows and 84,906 SNPs remained for GWAS work; as a result, we identified 20 significant SNPs after Bonferroni correction. Several candidate genes were identified within distances of 200 kb upstream or downstream to the significant SNPs, including

Indexed as

Chinese Holstein cowFarmCPUfeet and legfunctional analysisGWASSNP

Identifiers

PMID34438715
PMCPMC8388412

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.