Evidence map›Paper›PMID 34439262›Full record

ReviewCancers2021

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer.

Kanika Singh, Nazim Nassar, Ava Bachari, Ellen Schanknecht, Srinivasareddy Telukutla, Roby Zomer, Terrence J Piva, Nitin Mantri

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review.International journal of molecular sciences · 2026
    Review
  3. Current and Potential Use of Biologically Active Compounds Derived fromInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CBInternational journal of molecular sciences · 2023
    Article
  12. The androgen receptor-targeted proteolysis targeting chimera and other alternative therapeutic choices in overcoming the resistance to androgen deprivation treatment in prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kanika SinghThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.
Nazim NassarSchool of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
Ava BachariThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.ORCID 0000-0002-9864-2794
Ellen SchanknechtThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.
Srinivasareddy TelukutlaThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.
Roby ZomerMGC Pharmaceuticals Limited, West Perth, WA 6005, Australia.
Terrence J PivaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.ORCID 0000-0003-0343-1781
Nitin MantriThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.ORCID 0000-0002-7621-035X
RMIT University · AUThe University of Western Australia · AU

Funding

MGC Pharmaceuticals Pty Ltd Not Applicable
6 · The paper itself

Abstract

Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.

Indexed as

cancercannabinoid receptorscannabinoidscannabisprostate cancer

Identifiers

PMID34439262
PMCPMC8392233
OpenAlexW3193428825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.