Evidence map›Paper›PMID 34439467›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Impact of EcSOD Perturbations in Cancer Progression.

Brianne R O'Leary, Rory S Carroll, Garett J Steers, Jennifer Hrabe, Frederick E Domann, Joseph J Cullen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brianne R O'LearyDepartment of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.ORCID 0000-0001-7431-1141
Rory S CarrollDepartment of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.ORCID 0000-0001-6622-0231
Garett J SteersDepartment of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.ORCID 0000-0001-9210-9828
Jennifer HrabeDepartment of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.
Frederick E DomannDepartment of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA 52246, USA.ORCID 0000-0002-0489-2179
Joseph J CullenDepartment of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.ORCID 0000-0002-2222-1328
University of Iowa · US

Funding

Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
University of Iowa Surgical Oncology Training GrantT32CA148062 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2010 to 2020
$3.8M
NCI NIH HHS P01 CA217797NIH HHS P01CA217797NIH HHS T32 CA148062
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are a normal byproduct of cellular metabolism and are required components in cell signaling and immune responses. However, an imbalance of ROS can lead to oxidative stress in various pathological states. Increases in oxidative stress are one of the hallmarks in cancer cells, which display an altered metabolism when compared to corresponding normal cells. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide anion (O

Indexed as

cancerextracellular superoxide dismutase (EcSOD)reactive oxygen species (ROS)

Identifiers

PMID34439467
PMCPMC8388922
OpenAlexW3183756125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.