Evidence map›Paper›PMID 34440238›Full record

ArticleBiomedicines2021

Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction.

Mohamed M Ali, Chandra Hassan, Mario Masrur, Francesco M Bianco, Dina Naquiallah, Imaduddin Mirza, Patrice Frederick, Eduardo T Fernandes, Cristoforo P Giulianotti, Antonio Gangemi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamed M AliDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8085-7132
Chandra HassanDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Mario MasrurDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Francesco M BiancoDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Dina NaquiallahDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Imaduddin MirzaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Patrice FrederickDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Eduardo T FernandesDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Cristoforo P GiulianottiDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Antonio GangemiDepartments of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Shane A PhillipsDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Abeer M MahmoudDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-0295-6706

Funding

Shedding of Endothelial Glycocalyx in Morbidly Obese PatientsR00HL140049 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOHAMED, ABEER M · 2019 to 2021
$889k
DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight LossK99HL140049 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOHAMED, ABEER M · 2018 to 2019
$213k
NHLBI NIH HHS R00 HL140049NIH HHS 4 R00 HL140049-03NIH HHS K99HL140049
6 · The paper itself

Abstract

Obesity is characterized by the accumulation of dysfunctional adipose tissues, which predisposes to cardiometabolic diseases. Our previous in vitro studies demonstrated a role of hypoxia in inducing adipokine hypomethylation in adipocytes. We sought to examine this mechanism in visceral adipose tissues (VATs) from obese individuals and its correlation with cardiometabolic risk factors. We propose an involvement of the hypoxia-inducible factor, HIF1α, and the DNA hydroxymethylase, TET1. Blood samples and VAT biopsies were obtained from obese and non-obese subjects (

Indexed as

adipokinesDNA methylationflow-induced dilationhypoxiainflammationnitric oxideobesityTET1vascular dysfunctionvisceral adipose tissue

Identifiers

PMID34440238
PMCPMC8394952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.