Evidence map›Paper›PMID 34440582›Full record

ReviewLife (Basel, Switzerland)2021

Towards Next Generation Biomarkers in Natural Killer/T-Cell Lymphoma.

Jason Yongsheng Chan, Jing Quan Lim, Choon Kiat Ong

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jason Yongsheng ChanDivision of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.
Jing Quan LimLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.ORCID 0000-0003-3732-8707
Choon Kiat OngLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.ORCID 0000-0001-6402-4288
Agency for Science, Technology and Research · SGDuke-NUS Medical School · SGSingHealth Duke-NUS Academic Medical Centre · SG

Funding

Ling Foundation NRDUKSN18101National Medical Research Council NMRC/Fellowship/0054/2017National Medical Research Council NMRC-OFIRG16NOV090National Medical Research Council NMRC-OFLCG-18May0028National Medical Research Council TCR/010-NCC/2012New Century Foundation NCCRF-YR2014-SEP-SD2SHF-Foundation Research Grant SHF/FG653P/2017SingHealth Duke-NUS Academic Medical Centre and Oncology ACP Nurturing Clinician Scientist Scheme 08-FY2017/P1/14-A28Tanoto Foundation NRDUKST18101
6 · The paper itself

Abstract

Natural killer/T-cell lymphoma (NKTCL) is an Epstein-Barr virus-associated non-Hodgkin lymphoma linked to an aggressive clinical course and poor prognosis. Despite an improvement in survival outcomes with the incorporation of novel agents including immune checkpoint inhibitors in the treatment of NKTCL, a significant proportion of patients still relapse or remain refractory to treatment. Several clinical prognostic models have been developed for NKTCL patients treated in the modern era, though the optimal approach to risk stratification remains to be determined. Novel molecular biomarkers derived from multi-omic profiling have recently been developed, with the potential to improve diagnosis, prognostication and treatment of this disease. Notably, a number of potential biomarkers have emerged from a better understanding of the tumor immune microenvironment and inflammatory responses. This includes a recently described 3'UTR structural variant in the

Indexed as

EBVimmunotherapyPD-L1precision oncologyprognosis

Identifiers

PMID34440582
PMCPMC8398475
OpenAlexW3196094291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.