Evidence map›Paper›PMID 34440738›Full record

ArticleCells2021

Loosening ER-Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain.

Michela Rossini, Paloma García-Casas, Riccardo Filadi, Paola Pizzo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis.Journal of Alzheimer's disease : JAD · 2024
    Article
  6. Review
  7. Review
  8. Sustained IP3-linked CaFrontiers in cell and developmental biology · 2023
    Article
  9. Article
  10. Article
  11. Endoplasmic reticulum-Mitochondria Coupling in Alzheimer's Disease.Contact (Thousand Oaks (Ventura County, Calif.))
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michela RossiniDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Paloma García-CasasDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Riccardo FiladiDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Paola PizzoDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.ORCID 0000-0001-6077-3265
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer's disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide formation. In particular, its enrichment in endoplasmic reticulum (ER) membrane domains close to mitochondria (i.e., mitochondria-associated membranes, MAM) enables PS2 to modulate multiple processes taking place on these signaling hubs, such as Ca

Indexed as

Alzheimer DiseaseCalciumCell Line, TumorCytosolEndoplasmic ReticulumFibroblastsHumansLipid DropletsMitochondriaMutagenesisPresenilin-1Presenilin-2Protein DomainsCalciumPresenilin-1Presenilin-2Alzheimer’s diseaseCa2+ signalingERMAMmitochondriaorganelle contactsPresenilin 2

Identifiers

PMID34440738
PMCPMC8394530
OpenAlexW3192746139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.