Evidence map›Paper›PMID 34440839›Full record

ArticleCells2021

The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation.

Jami M Gurley, Grzegorz B Gmyrek, Elizabeth A Hargis, Gail A Bishop, Daniel J J Carr, Michael H Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jami M GurleyDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.ORCID 0000-0002-7919-9328
Grzegorz B GmyrekDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.
Elizabeth A HargisDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.
Gail A BishopDepartment of Microbiology and Immunology, University of Iowa and VAMC, Iowa City, IA 52242, USA.ORCID 0000-0002-1291-5078
Daniel J J CarrDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.
Michael H ElliottDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA.ORCID 0000-0002-2289-8718
Dean McGee Eye Institute · USUniversity of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
The Neuroimmunology of Viral InfectionR01AI053108 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CARR, DANIEL J · 2003 to 2022
$5.8M
Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier IntegrityR01EY019494 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ELLIOTT, MICHAEL H · 2010 to 2025
$4.9M
The Roles of TRAF3 in Lymphocyte SignalingR01AI028847 · NIAID · UNIVERSITY OF IOWA · PI BISHOP, GAIL A. · 1996 to 2011
$3.1M
Vision Science Training ProgramT32EY023202 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2014 to 2025
$952k
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY019494NEI NIH HHS T32 EY023202NIAID NIH HHS R01 AI028847NIAID NIH HHS R01 AI053108NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Uncontrolled inflammation is associated with neurodegenerative conditions in central nervous system tissues, including the retina and brain. We previously found that the neural retina (NR) plays an important role in retinal immunity. Tumor necrosis factor Receptor-Associated Factor 3 (TRAF3) is a known immune regulator expressed in the retina; however, whether TRAF3 regulates retinal immunity is unknown. We have generated the first conditional NR-

Indexed as

AnimalsDisease Models, AnimalElectroretinographyHomeodomain ProteinsImmunityLipopolysaccharidesMacrophagesMiceMice, KnockoutNeuronsReceptors, CCR2RetinaTNF Receptor-Associated Factor 3Transcription FactorsUveitisVisual AcuityCcr2 protein, mouseHomeodomain ProteinsLipopolysaccharidesReceptors, CCR2TNF Receptor-Associated Factor 3Transcription FactorsVsx2 protein, mousecentral nervous systemimmunityinflammationlipopolysaccharideneural retinaneurodegenerationTraf3vision

Identifiers

PMID34440839
PMCPMC8391412
OpenAlexW3190269724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.