Evidence map›Paper›PMID 34444718›Full record

SynthesisNutrients2021

Oat Intake and Risk of Type 2 Diabetes, Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis.

Faina Wehrli, Petek E Taneri, Arjola Bano, Lia Bally, Lauren C Blekkenhorst, Weston Bussler, Brandon Metzger, Beatrice Minder, Marija Glisic, Taulant Muka and 1 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07371598 (Impact of Royal Ancient Oats™ on Glycemic Response and Digestive Enzymes), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07371598 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Royal Ancient Oats™ on Glycemic Response and Digestive Enzymes

TypeinterventionalSponsorStandard Process Inc.Ran2026 to 2026Enrolled38ConditionsHealthy Participants, Healthy GlucoseArmsRoyal Ancient Oat Flour™
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Ameliorative and Antioxidative Potential ofAntioxidants (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Faina WehrliInstitute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-0520-0362
Petek E TaneriInstitute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-0399-3584
Arjola BanoInstitute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland.
Lia BallyDepartment of Diabetes, Endocrinology, Nutritional Medicine, and Metabolism, Inselspital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-1993-7672
Lauren C BlekkenhorstSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Weston BusslerStandard Process Nutrition Innovation Center, Kannapolis, NC 28018, USA.
Brandon MetzgerStandard Process Nutrition Innovation Center, Kannapolis, NC 28018, USA.
Beatrice MinderPublic Health & Primary Care Library, University Library of Bern, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-1345-2594
Marija GlisicInstitute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland.
Taulant MukaInstitute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland.
Hua KernStandard Process Nutrition Innovation Center, Kannapolis, NC 28018, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain the top disease and mortality burdens worldwide. Oats have been shown to benefit cardiovascular health and improve insulin resistance. However, the evidence linking oat consumption with CVD, T2D and all-cause mortality remains inconclusive. We conducted a comprehensive systematic review and meta-analysis of prospective cohort studies to evaluate the associations between oat consumption and risks of T2D, CVD and all-cause mortality in the general population. Five electronic databases were searched until September, 2020. Study specific relative risks (RR) were meta-analyzed using random effect models. Of 4686 relevant references, we included 9 articles, based on 8 unique studies and 471,157 participants. Comparing oat consumers versus non-consumers, RRs were 0.86 (95% CI 0.72-1.03) for T2D incidence and 0.73 (95% CI 0.5-1.07) for combined CVD incidence. Comparing participants with highest versus lowest oat intake, RRs were 0.78 (95% CI 0.74-0.82) for T2D incidence, 0.81 (95% CI 0.61-1.08) for CHD incidence and 0.79 (95% CI 0.59-1.07) for stroke. For all-cause mortality one study based on three cohorts found RR for men and women were 0.76 (95% CI 0.69-0.85) and 0.78 (95% CI 0.70-0.87), respectively. Most studies (

Indexed as

AvenaMortalityWhole GrainsCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleRiskStrokecardiovascular diseasemortalityoattype 2 diabetes

Identifiers

PMID34444718
PMCPMC8398256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.