Evidence map›Paper›PMID 34444792›Full record

SynthesisNutrients2021

Does Sodium Intake Induce Systemic Inflammatory Response? A Systematic Review and Meta-Analysis of Randomized Studies in Humans

Eirini D Basdeki, Anastasios Kollias, Panagiota Mitrou, Christiana Tsirimiagkou, Marios K Georgakis, Antonios Chatzigeorgiou, Antonios Argyris, Kalliopi Karatzi, Yannis Manios, Petros P Sfikakis and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Eirini D BasdekiCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Anastasios KolliasHypertension Center STRIDE-7, Third Department of Medicine, School of Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, 11527 Athens, Greece.ORCID 0000-0002-2098-1665
Panagiota MitrouHellenic Republic Ministry of Health, 10433 Athens, Greece.
Christiana TsirimiagkouCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-0203-5309
Marios K GeorgakisInstitute for Stroke and Dementia Research, University Hospital, Ludwig Maximilians University, 81377 Munich, Germany.
Antonios ChatzigeorgiouDepartment of Physiology, Medical School, National & Kapodistrian University of Athens, 11527 Athens, Greece.
Antonios ArgyrisCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-8906-6959
Kalliopi KaratziDepartment of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.ORCID 0000-0001-5453-898X
Yannis ManiosDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Kallithea, Greece.ORCID 0000-0001-6486-114X
Petros P SfikakisFirst Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko Hospital, 11527 Athens, Greece.
Athanase D ProtogerouCardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-3825-532X
National and Kapodistrian University of Athens · GRAgricultural University of Athens · GRHarokopio University of Athens · GRLaiko General Hospital of Athens · GRLudwig-Maximilians-Universität München · DEMinistry of Health · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental studies suggest that sodium induced inflammation might be another missing link leading to atherosclerosis. To test the hypothesis that high daily sodium intake induces systemic inflammatory response in humans, we performed a systematic review according to PRISMA guidelines of randomized controlled trials (RCTs) that examined the effect of high versus low sodium dose (HSD vs. LSD), as defined per study, on plasma circulating inflammatory biomarkers. Eight RCTs that examined CRP, TNF-a and IL-6 were found. Meta-analysis testing the change of each biomarker in HSD versus LSD was possible for CRP (

Indexed as

Systemic Inflammatory Response SyndromeBiomarkersBlood PressureDatabases, FactualHumansInflammationInterleukin-6Randomized Controlled Trials as TopicSodium, DietaryTumor Necrosis Factor-alphaBiomarkersInterleukin-6Sodium, DietaryTNF protein, humanTumor Necrosis Factor-alphaCRPIL-6inflammationsodiumsodium induced inflammationsodium intakesystemic inflammationTNF-a

Identifiers

PMID34444792
PMCPMC8399701
OpenAlexW3184957868

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.