Evidence map›Paper›PMID 34444945›Full record

ArticleNutrients2021

Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyses in Mice.

Philibert Duriez, Ida A K Nilsson, Ophelia Le Thuc, David Alexandre, Nicolas Chartrel, Carole Rovere, Christophe Chauveau, Philip Gorwood, Virginie Tolle, Odile Viltart

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Contextualising Physical Activity Levels in Patients With Anorexia Nervosa: A Systematic Review and Meta-Analysis.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Pooled it
  2. Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Philibert DuriezInstitute of Psychiatry and Neuroscience of Paris (IPNP), University of Paris, INSERM UMR-S 1266, F-75014 Paris, France.ORCID 0000-0001-7321-6820
Ida A K NilssonDepartment of Molecular Medicine & Surgery, Karolinska Institutet, Centre for Eating Disorders Innovation (CEDI), Medical University, Karolinska Institutet, S-17176 Stockholm, Sweden.ORCID 0000-0002-7676-4299
Ophelia Le ThucCNRS UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC), University of Nice-Sophia Antipolis, F-06560 Valbonne, France.ORCID 0000-0001-8154-9916
David AlexandreINSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, University of Normandie, UNIROUEN, F-76821 Mont-Saint-Aignan, France.ORCID 0000-0003-4811-0818
Nicolas ChartrelINSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, University of Normandie, UNIROUEN, F-76821 Mont-Saint-Aignan, France.
Carole RovereCNRS UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC), University of Nice-Sophia Antipolis, F-06560 Valbonne, France.
Christophe ChauveauMarrow Adiposity and Bone Laboratory (MABLab), University of Littoral Côté d'Opale, CHRU Lille, F-62327 Boulogne sur Mer, France.
Philip GorwoodInstitute of Psychiatry and Neuroscience of Paris (IPNP), University of Paris, INSERM UMR-S 1266, F-75014 Paris, France.ORCID 0000-0003-1845-3676
Virginie TolleInstitute of Psychiatry and Neuroscience of Paris (IPNP), University of Paris, INSERM UMR-S 1266, F-75014 Paris, France.
Odile ViltartInstitute of Psychiatry and Neuroscience of Paris (IPNP), University of Paris, INSERM UMR-S 1266, F-75014 Paris, France.ORCID 0000-0002-4801-3586
Inserm · FRCentre National de la Recherche Scientifique · FRKarolinska Institutet · SEUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, a significant part of patients experience relapses. In this translational study, we combined clinical and preclinical approaches. We describe preliminary data about the effect of weight gain on the symptomatology of patients suffering from acute AN (

Indexed as

ExerciseAdolescentAdultAnimalsAnorexia NervosaBody Mass IndexBody WeightFeeding BehaviorFemaleGhrelinHeart RateHumansHypothalamusLeptinMiceMice, Inbred C57BLacyl-ghrelinGhrelinghrelin, des-n-octanoylLeptinNeuropeptidesRNA, Messengeranimal modelanorexia nervosabody mass indexghrelinheart ratehypothalamusleptinneuropeptidesphysical activity

Identifiers

PMID34444945
PMCPMC8401511
OpenAlexW3193798631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.