Evidence map›Paper›PMID 34444964›Full record

ReviewNutrients2021

Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool.

Valeria Calcaterra, Elvira Verduci, Martina Chiara Pascuzzi, Vittoria Carlotta Magenes, Giulia Fiore, Elisabetta Di Profio, Elisavietta Tenuta, Alessandra Bosetti, Carolina Federica Todisco, Enza D'Auria and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Effect of Ketogenic Diet on Obesity and Other Metabolic Disorders: Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Valeria CalcaterraPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2137-5974
Elvira VerduciPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0003-2111-3111
Martina Chiara PascuzziPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0003-3549-498X
Vittoria Carlotta MagenesPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Giulia FiorePediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Elisabetta Di ProfioPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Elisavietta TenutaPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Alessandra BosettiPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Carolina Federica TodiscoPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Enza D'AuriaPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0003-2750-5810
Gianvincenzo ZuccottiPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-2795-9874
University of Milan · ITUniversity of Pavia · ITOspedale dei Bambini Vittore Buzzi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is defined as a condition characterized by an excessive fat accumulation that has negative health consequences. Pediatric obesity is associated with an increased risk for many diseases, including impaired glycemic and lipidic control that may lead to the development of chronic, and potentially disabling, pathologies, such as type 2 diabetes mellitus (T2DM) and cardiovascular events, in adult life. The therapeutic strategy initially starts with interventions that are aimed at changing lifestyle and eating behavior, to prevent, manage, and potentially reverse metabolic disorders. Recently, the ketogenic diet (KD) has been proposed as a promising dietary intervention for the treatment of metabolic and cardiovascular risk factors related to obesity in adults, and a possible beneficial role has also been proposed in children. KD is very low in carbohydrate, high in fat, and moderate to high in protein that may have the potential to promote weight loss and improve lipidic derangement, glycemic control, and insulin sensitivity. In this review, we present metabolic disorders on glycemic and lipidic control in children and adolescents with obesity and indication of KD in pediatrics, discussing the role of KD as a therapeutic tool for metabolic derangement. The results of this review may suggest the validity of KD and the need to further research its potential to address metabolic risk factors in pediatric obesity.

Indexed as

Diet, KetogenicAdolescentChildDiabetes Mellitus, Type 2HumansInsulin ResistanceMetabolic DiseasesPediatric Obesitydiabetesinsulin resistanceketogenic dietlipidsobesity

Identifiers

PMID34444964
PMCPMC8400548
OpenAlexW3194822211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.