Evidence map›Paper›PMID 34445161›Full record

ArticleInternational journal of molecular sciences2021

NGS Analysis Confirms Common

Cornelia Peterson, Robert Moore, Jessica L Hicks, Laura A Morsberger, Angelo M De Marzo, Ying Zou, Charles G Eberhart, Ashley A Campbell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Cornelia PetersonDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6550-1883
Robert MooreDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jessica L HicksDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Laura A MorsbergerDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Angelo M De MarzoDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ying ZouDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Charles G EberhartDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ashley A CampbellDepartment of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins University · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
NIH HHS T32 OD011089
6 · The paper itself

Abstract

Ocular adnexal (OA) sebaceous carcinomas generally demonstrate more aggressive clinical and histopathological phenotypes than extraocular cases, but the molecular drivers implicated in their oncogenesis remain poorly defined. A retrospective review of surgical and ocular pathology archives identified eleven primary resection specimens of OA sebaceous carcinomas with adequate tissue for molecular analysis; two extraocular cases were also examined. Next-generation sequencing was used to evaluate mutations and copy number changes in a large panel of cancer-associated genes. Fluorescence in situ hybridization (FISH) confirmed

Indexed as

AgedAged, 80 and overEye NeoplasmsFemaleGene DosageHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationNeoplasms, Adnexal and Skin AppendageProto-Oncogene Proteins c-mycRetinoblastoma Binding ProteinsSebaceous Gland NeoplasmsTumor Suppressor Protein p53Ubiquitin-Protein LigasesMYC protein, humanProto-Oncogene Proteins c-mycRB1 protein, humanRetinoblastoma Binding ProteinsTP53 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein LigasesMYCnext-generation sequencingocular adnexal tumorsebaceous carcinoma

Identifiers

PMID34445161
PMCPMC8395148
OpenAlexW3187800033

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.