Evidence map›Paper›PMID 34445262›Full record

ArticleInternational journal of molecular sciences2021

Co-Aggregation of S100A9 with DOPA and Cyclen-Based Compounds Manifested in Amyloid Fibril Thickening without Altering Rates of Self-Assembly.

Lili Arabuli, Igor A Iashchishyn, Nina V Romanova, Greta Musteikyte, Vytautas Smirnovas, Himanshu Chaudhary, Željko M Svedružić, Ludmilla A Morozova-Roche

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Lili ArabuliDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90781 Umeå, Sweden.
Igor A IashchishynDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90781 Umeå, Sweden.ORCID 0000-0002-1691-9025
Nina V RomanovaDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90781 Umeå, Sweden.
Greta MusteikyteInstitute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.
Vytautas SmirnovasInstitute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.ORCID 0000-0002-1829-5455
Himanshu ChaudharyDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90781 Umeå, Sweden.
Željko M SvedružićDepartment of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia.ORCID 0000-0002-0736-6182
Ludmilla A Morozova-RocheDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90781 Umeå, Sweden.ORCID 0000-0001-5886-2023
Umeå University · SEVilnius University · LTUniversity of Georgia · GEUniversity of Rijeka · HR

Funding

Demensfonden 2020-04-17Forskningsstrategiska medel, Medical Faculty, Umeå University 2019-75Insamlingsstiftelsen 2019-11Kempe Foundation U24 2021Medicinska Forskningsrådet 2019-01232
6 · The paper itself

Abstract

The amyloid cascade is central for the neurodegeneration disease pathology, including Alzheimer's and Parkinson's, and remains the focus of much current research. S100A9 protein drives the amyloid-neuroinflammatory cascade in these diseases. DOPA and cyclen-based compounds were used as amyloid modifiers and inhibitors previously, and DOPA is also used as a precursor of dopamine in Parkinson's treatment. Here, by using fluorescence titration experiments we showed that five selected ligands: DOPA-D-H-DOPA, DOPA-H-H-DOPA, DOPA-D-H, DOPA-cyclen, and H-E-cyclen, bind to S100A9 with apparent K

Indexed as

Molecular Dynamics SimulationProtein AggregatesAmyloidCalgranulin BDihydroxyphenylalanineHumansAmyloidCalgranulin BDihydroxyphenylalanineProtein AggregatesS100A9 protein, humanamyloidbindingcyclenDOPAmorphologyS100A9

Identifiers

PMID34445262
PMCPMC8395260
OpenAlexW3192548310

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.