Evidence map›Paper›PMID 34445362›Full record

ReviewInternational journal of molecular sciences2021

Receptor-Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors.

Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Guido Maura, Luigi F Agnati

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diego GuidolinDepartment of Neuroscience, Section of Anatomy, University of Padova, 35121 Padova, Italy.ORCID 0000-0003-2133-3552
Cinzia TortorellaDepartment of Neuroscience, Section of Anatomy, University of Padova, 35121 Padova, Italy.
Manuela MarcoliDepartment of Pharmacy, Center of Excellence for Biomedical Research, University of Genova, 16126 Genova, Italy.
Chiara CervettoDepartment of Pharmacy, Center of Excellence for Biomedical Research, University of Genova, 16126 Genova, Italy.ORCID 0000-0001-8290-3008
Guido MauraDepartment of Pharmacy, Center of Excellence for Biomedical Research, University of Genova, 16126 Genova, Italy.
Luigi F AgnatiDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery that receptors from all families can establish allosteric receptor-receptor interactions and variably associate to form receptor complexes operating as integrative input units endowed with a high functional and structural plasticity has expanded our understanding of intercellular communication. Regarding the nervous system, most research in the field has focused on neuronal populations and has led to the identification of many receptor complexes representing an important mechanism to fine-tune synaptic efficiency. Receptor-receptor interactions, however, also modulate glia-neuron and glia-glia intercellular communication, with significant consequences on synaptic activity and brain network plasticity. The research on this topic is probably still at the beginning and, here, available evidence will be reviewed and discussed. It may also be of potential interest from a pharmacological standpoint, opening the possibility to explore, inter alia, glia-based neuroprotective therapeutic strategies.

Indexed as

Allosteric RegulationAnimalsCell CommunicationHumansNeurogliaNeuronsProtein Interaction MapsReceptors, G-Protein-CoupledReceptors, G-Protein-Coupledallosteryglial cellsGPCRoligomerizationreceptor–receptor interactions

Identifiers

PMID34445362
PMCPMC8395429

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.