Evidence map›Paper›PMID 34445476›Full record

ArticleInternational journal of molecular sciences2021

Worsening of the Toxic Effects of (±)

Micaela Tirri, Paolo Frisoni, Sabrine Bilel, Raffaella Arfè, Claudio Trapella, Anna Fantinati, Giorgia Corli, Beatrice Marchetti, Fabio De-Giorgio, Cristian Camuto and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. 4,4'-DMARFrontiers in cardiovascular medicine · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Micaela TirriLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-9337-9184
Paolo FrisoniDepartment of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4862-2215
Sabrine BilelLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
Raffaella ArfèLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
Claudio TrapellaDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Anna FantinatiDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0437-5670
Giorgia CorliLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
Beatrice MarchettiLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
Fabio De-GiorgioDepartment of Health Care Surveillance and Bioetics, Section of Legal Medicine, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Cristian CamutoLaboratorio Antidoping FMSI, Largo Giulio Onesti 1, 00197 Rome, Italy.
Monica MazzarinoLaboratorio Antidoping FMSI, Largo Giulio Onesti 1, 00197 Rome, Italy.
Rosa Maria GaudioLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
Giovanni SerpelloniNeuroscience Clinical Center & TMS Unit, 37138 Verona, Italy.
Fabrizio SchifanoPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Francesco BotrèLaboratorio Antidoping FMSI, Largo Giulio Onesti 1, 00197 Rome, Italy.ORCID 0000-0001-5296-8126
Matteo MartiLTTA Center and University Center of Gender Medicine, Department of Translational Medicine, Section of Legal Medicine, University of Ferrara, 44121 Ferrara, Italy.
University of Ferrara · ITFederazione Medico Sportiva Italiana · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Florida · USUniversity of Hertfordshire · GB

Funding

Anti-Drug Policies Department, Presidency of the Council of Ministers, Italy Effects of NPS: development of a multicentre research for the information enhancement of the Early Warning SystemCatholic University of Rome Linea D1 grantsItalian Ministry of Education, University and Research RBFR12LDOWUniversity of Ferrara, Italy FAR 2019University of Ferrara, Italy FAR 2020
6 · The paper itself

Abstract

4,4'-Dimethylaminorex (4,4'-DMAR) is a new synthetic stimulant, and only a little information has been made available so far regarding its pharmaco-toxicological effects. The aim of this study was to investigate the effects of the systemic administration of both the single (±)

Indexed as

AnimalsBehavior, AnimalMaleMiceMice, Inbred ICROxazolesPsychophysiologic DisordersPsychotropic DrugsStereoisomerismOxazolespara-methyl-4-methylaminorexPsychotropic Drugs4-4′-DMARapoptosiscortexdrug metabolismhyperthermiaimmunohistochemistryneurotoxicitynovel psychoactive substancesoxidative/nitrosative stressstimulant

Identifiers

PMID34445476
PMCPMC8395767
OpenAlexW3193606952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.