Evidence map›Paper›PMID 34445542›Full record

ArticleInternational journal of molecular sciences2021

Endoglin Is an Endothelial Housekeeper against Inflammation: Insight in ECFC-Related Permeability through LIMK/Cofilin Pathway.

Elisa Rossi, Alexandre Kauskot, François Saller, Elisa Frezza, Sonia Poirault-Chassac, Anna Lokajczyk, Pierre Bourdoncle, Bruno Saubaméa, Pascale Gaussem, Miguel Pericacho and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Elisa RossiFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0002-0570-6104
Alexandre KauskotHITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.ORCID 0000-0002-4064-8114
François SallerHITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Elisa FrezzaFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0003-0122-7859
Sonia Poirault-ChassacFaculty of Pharmacy, University of Paris, F-75006 Paris, France.
Anna LokajczykFaculty of Pharmacy, University of Paris, F-75006 Paris, France.
Pierre BourdonclePlate-Forme IMAG'IC Institut Cochin Inserm U1016-CNRS UMR8104, Université Paris Descartes, F-75006 Paris, France.
Bruno SaubaméaFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0002-6218-0460
Pascale GaussemFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0002-9139-2147
Miguel PericachoDepartment of Physiology and Pharmacology, Universidad de Salamanca, 37008 Salamanca, Spain.ORCID 0000-0003-0226-482X
Regis BobeHITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.ORCID 0000-0002-8225-9117
Christilla Bachelot-LozaFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0002-6264-902X
Samuela PasqualiFaculty of Pharmacy, University of Paris, F-75006 Paris, France.
Carmelo BernabeuCentro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, Spain.ORCID 0000-0002-1563-6162
David M SmadjaFaculty of Pharmacy, University of Paris, F-75006 Paris, France.ORCID 0000-0001-7731-9202
Inserm · FRCentre National de la Recherche Scientifique · FRConsejo Superior de Investigaciones Científicas · ESUniversidad de Salamanca · ESUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoglin (Eng) is an endothelial cell (EC) transmembrane glycoprotein involved in adhesion and angiogenesis. Eng mutations result in vessel abnormalities as observed in hereditary hemorrhagic telangiectasia of type 1. The role of Eng was investigated in endothelial functions and permeability under inflammatory conditions, focusing on the actin dynamic signaling pathway. Endothelial Colony-Forming Cells (ECFC) from human cord blood and mouse lung/aortic EC (MLEC, MAEC) from

Indexed as

Cell Membrane PermeabilityActin Depolymerizing FactorsAnimalsEndoglinEndothelial CellsInflammationLim KinasesMiceNeovascularization, PathologicActin Depolymerizing FactorsEndoglinLIMK1 protein, humanLim KinasescofilinECFCendoglinHHT1TNFα

Identifiers

PMID34445542
PMCPMC8396367
OpenAlexW3194724471

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.