Evidence map›Paper›PMID 34445549›Full record

ArticleInternational journal of molecular sciences2021

Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells.

Fangfang Tie, Jin Ding, Na Hu, Qi Dong, Zhi Chen, Honglun Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Overexpression ofaBIOTECH · 2026
    Article
  3. Review
  4. Sequential Fractionation ofFoods (Basel, Switzerland) · 2026
    Article
  5. Molecules (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Review
  8. Effects ofInternational journal of molecular sciences · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Kaempferol-A Natural Drug for Rheumatoid Arthritis.Chinese journal of integrative medicine · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fangfang TieCAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.ORCID 0000-0002-9466-585X
Jin DingCAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
Na HuCAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
Qi DongCAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.ORCID 0000-0002-6192-1597
Zhi ChenKey Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibetan Plateau in Qinghai Province, Xining 810008, China.
Honglun WangCAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.ORCID 0000-0002-9882-9604
Institute of Tibetan Plateau Research · CNQinghai Tibetan Hospital · CN

Funding

Innovation Platform for the Development and Construction of Special Project of Qinghai Province 2021-ZJ-T05Key Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibetan Plateau in Qinghai Province 2020-ZJ-Y40National Natural Science Foundation of China 31870333, 31800297Qinghai Provincial Science Foundation 2020-SF-A2, 2020-ZJ-905
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases which lacks ideal treatment options. Kaempferol and kaempferide, two natural flavonol compounds isolated from

Indexed as

Carcinoma, HepatocellularFatty LiverHep G2 CellsHumansKaempferolsLipogenesisLiver NeoplasmsOleic AcidOxidative StressSignal TransductionkaempferidekaempferolKaempferolsOleic Acidkaempferidekaempferollipid accumulationmolecular dockingNAFLDoxidative stress

Identifiers

PMID34445549
PMCPMC8396315
OpenAlexW3193972753

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.