Evidence map›Paper›PMID 34445697›Full record

ReviewInternational journal of molecular sciences2021

From Fighting Critters to Saving Lives: Polyphenols in Plant Defense and Human Health.

Amber Stiller, Kendall Garrison, Karina Gurdyumov, Jacob Kenner, Farida Yasmin, Ping Yates, Bao-Hua Song

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Unlocking the Functional Value of European-OriginatedMolecules (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. FeScientific reports · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same?International journal of molecular sciences · 2024
    Review
  20. Four New Furofuran Lignans fromInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amber StillerDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Kendall GarrisonDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.ORCID 0000-0002-2987-7151
Karina GurdyumovDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Jacob KennerDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Farida YasminDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.ORCID 0000-0002-4621-7796
Ping YatesDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Bao-Hua SongDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.ORCID 0000-0003-3537-7783
University of North Carolina at Charlotte · US

Funding

Molecular basis and evolution of complex trait variation with significance in human healthR15GM122029 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI SONG, BAO-HUA · 2016 to 2016
$439k
NIGMS NIH HHS R15 GM122029NIH HHS R15GM122029North Carolina Biotechnology Center 2019-BIG-6507North Carolina Biotechnology Center 2020-FLG-3806The North Carolina Soybean Producers Association 18-0252University of North Carolina at Charlotte Song_FRG_2020
6 · The paper itself

Abstract

Polyphenols, such as flavonoids and phenolic acids, are a group of specialized metabolites in plants that largely aid in plant defense by deterring biotic stressors and alleviating abiotic stress. Polyphenols offer a wide range of medical applications, acting as preventative and active treatments for diseases such as cancers and diabetes. Recently, researchers have proposed that polyphenols may contribute to certain applications aimed at tackling challenges related to the COVID-19 pandemic. Understanding the beneficial impacts of phytochemicals, such as polyphenols, could potentially help prepare society for future pandemics. Thus far, most reviews have focused on polyphenols in cancer prevention and treatment. This review aims to provide a comprehensive discussion on the critical roles that polyphenols play in both plant chemical defense and human health based on the most recent studies while highlighting prospective avenues for future research, as well as the implications for phytochemical-based applications in both agricultural and medical fields.

Indexed as

AnimalsAnti-Inflammatory AgentsAntineoplastic AgentsAntiviral AgentsBiological AvailabilityCOVID-19COVID-19 Drug TreatmentFlavonoidsHumansHydroxybenzoatesHypoglycemic AgentsNeoplasmsPhytochemicalsPlantsPolyphenolsProspective StudiesAnti-Inflammatory AgentsAntineoplastic AgentsAntiviral AgentsFlavonoidsHydroxybenzoatesHypoglycemic Agentsphenolic acidPhytochemicalsPolyphenolsanti-viralschemical defensecrop improvementdisease preventionimmune systemphytochemicals

Identifiers

PMID34445697
PMCPMC8396434
OpenAlexW3193392476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.