ArticleEuropean heart journal2021
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.
Erratum issued 54 registry-linked trialsAbstract read
In one paragraph
Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 54 registered trials, which are not on this map. Cited by 6,090 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
6,090citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"An Open-label Clinical Trial to Evaluate the Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan in Adult Patients With Chronic Heart Failure With Reduced Ejection Fraction Associated With Congenital Heart Disease"
PMID 26787434PMID 26787728PMID 30415601PMID 30520545PMID 32865377PMID 33030857PMID 33186500PMID 33447845PMID 33832352PMID 33960724other papers from this trial
Open the trial in the graphEnhanced Diuresis and Natriuresis in Acute Decompensated Heart Failure Patients Treated With SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution: A Clinical Trial
PMID 36607775PMID 35241246PMID 32970396PMID 32709292PMID 32139695PMID 26240596PMID 22980301PMID 21885793PMID 21440872PMID 20607462PMID 15963399other papers from this trial
Open the trial in the graphEffect of Empagliflozin on Quality of Life in Chronic Heart Failure Patients With Diabetes Mellitus Type II
PMID 26378978PMID 28492288PMID 31466618PMID 35379503PMID 34556318PMID 34555929PMID 32865377other papers from this trial
Open the trial in the graphThe Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure
PMID 36530388PMID 11889012PMID 17543747PMID 19915891PMID 22157969PMID 27257850PMID 29472024PMID 29495980PMID 29663436PMID 30340887PMID 30895697PMID 31535829other papers from this trial
Open the trial in the graphEndovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fraction: Randomized Controlled Feasibility Trial - The Rebalance HF Study
The Safety of Dapagliflozin in Hemodialysis Patients With Heart Failure
Are There Any Differences in Occurrence of Lung Changes Associated With the Chronic Heart Failure Between the Patients With Preserved and Reduced Ejection Fraction of Left Ventricle?
Plasmatic Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids in Heart Failure
Evaluating the Safety and Efficacy of Atrial Shunt Implantation Systems for the Treatment of Patients With Chronic Left Heart Failure Prospective, Multicenter, Single-group Target Value Clinical Trials
Artificial Intelligence-Based Disease Management in the Vulnerable Period of Heart Failure, An Observational Study to Evaluate Patient Speech and Voice in the Vulnerable Phase of Heart Failure
NCT05572957 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation
Left Bundle Branch Pacing as Initial Therapy in Patients With Non-ischemic Heart Failure and Left Bundle Branch Block (LIT-HF Study)
Evaluation of the Progression of Disease and Health-related Quality of Life in Ambulatory Heart Failure Patients: A Local Clinic-based Registry
Medication Strategies in Heart Failure Patients Who Are Intolerable to Guideline-directed Medical Therapy
MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY (MAGIC-HF STUDY): Observational Study on Physiopathological, Diagnostic, Therapeutic, and Predictive Aspects of Heart Failure and Associated Comorbidities
Safety and Tolerability of Diuretics Withdrawal in Heart Failure With Reduced Ejection Fraction. REDICAE Trial.
Development of Longitudinal Multimarker Risk Models for Decision Support Across the Clinical Follow-up of Very Elderly Patients With Heart Failure and Preserved Ejection Fraction
Right Ventricular Dysfunction in Chronic Heart Failure: Clinical Laboratory and Echocardiographic Characteristics
A Dynamic Evaluation of Chronic Heart Failure Prognosis: the MECKI Score
Heart Failure Treatment Pattern Analysis of HF Patients in HF Centers and Non-HF Centers in China: a Retrospective Database-based Study
Biomarkers in Patients With Suspected Heart Failure With Preserved Ejection Fraction
Effects of VIRTUal reALity on Rehabilitation in Patients With Heart Failure: a Protocol for a Randomized Controlled Trial
ESTIA: TorasEmide Induced Effect on Quality of Life and Clinical parameterS in paTients With chronIc heArt Failure Receiving Eplerenone. Multicenter, Non-interventional, Prospective, Observational Clinical Study.
Description and Analysis of Congestion During Hospitalization for Acute Decompensated Heart Failure
Effects of High-intensity Interval Training on Myocardial Strain in Patients With Metabolic Syndrome
Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse Remodeling in Idiopathic Dilated Cardiomyopathy
Clinical Validation of an Artificial Intelligence Based Decision Support System for Predicting Risk, Diagnosis, and Progression of Heart Failure
Effects of 2-week Ketosis on Myocardial Ketone Body Consumption, Utilization, and External Efficiency in Patients With Chronic Heart Failure
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
Mechanistic Insights From Multisite Pacing in Patients With Heart Failure With Preserved Ejection Fraction
Spoke-hub shock protocol management according to scai class in turin and milan area
Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study
Randomized Embedded Multifactorial Adaptive Platform in ExtraCorporeal Membrane Oxygenation - Beta Receptor Modulation Trial
The Influence of Active Muscle Mass and Nitrate Supplementation on Fatigability in Individuals With Heart Failure
Clinical Findings and Albuminuria as Predictors of Acute Kidney Injury in Patients With Acute Heart Failure
Effect of a Person-centred Care Intervention on the Social Dimension of People With Chronic Heart Failure: A Randomised Controlled Trial
Optimizing Clinical Outcomes in Patients Undergoing M-TEER for Severe Functional Mitral Regurgitation Towards Improved Guideline-directed Medical Therapy - The MOTOR Registry
NCT06759077 phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation
Potential Beneficial Cardio Protective Effect of SGL2I in Hemodialysis Patients and Its Impact on Patient Quality of Life
An Observational Study to Collect High Resolution 12-Lead Electrocardiogram (ECG) Data for the Development of an ECG Library to Support the Development of a Tool to Monitor Disease Progression, Gather Patient Perspectives on Standard of Care Heart Failure Procedures and Facilitate Familiarity With the Clinical Trial Environment in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Uppsala Self-SCREENing of Heart Failure Study
Advanced Imaging With Photon Counting Computed Tomography in Heart Failure Patients: a Prospective Study
Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure
Effect of Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
QUAD-HF Registry - A Prospective Registry of Patients With Incident Heart Failure and Left Ventricular Ejection Fraction of <50%
NCT07243119 phase4enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
PRIMA-HF PRedicting Recovery of Left Ventricular Function With Multimodality Cardiac IMAging in Patients With de Novo Heart Failure HAI-HF: High-Dose Adenosine During Perfusion Imaging in Heart Failure: Rationale and Design of the HAI-HF Trial
NCT07295522 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
Endovascular Ablation Of The Right Greater Splanchnic Nerve In Subjects Having Heart Failure With Reduced Ejection Fraction: Randomized Controlled Feasibility Trial
The Role of a Structured Patient Education Programme in the Complex Care of Patients With Heart Failure
Comparison of the Effectiveness of Bolus and Infusion Diuretic Therapy in the Management of Acute Heart Failure in Emergency Departments: a Randomised, Double-blind Clinical Study
Detecting the Undetected: an Observational Cohort Study Evaluating the Health Economics, Clinical Utility, and Patient and Staff Experiences of Innovative Peptide Testing to Screen for Heart Failure in Lymphoedema Clinics
Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock
Improvement in Guideline-Directed Medical Therapy After Tricuspid Transcatheter Edge-to-Edge Repair in Participants With Reduced Left Ventricular Function
Urinary Sodium-Guided Optimization of Diuretic Therapy in Patients With Worsening Heart Failure: Rationale and Design of a Pragmatic Randomized Controlled Trial (SURE-HF Trial)
Evaluation of a Therapeutic Patient Education Program for Discharge (ETPsh) by Nurses in a French Hospital Setting Among Patients With Heart Failure
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Heart Failure Patients Presenting to Assiut University Heart Hospital.
Who cites it
6,090 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- "In-Hospital Initiation of SGLT-2 Inhibitors in Acute Heart Failure: A Systematic Review and Meta-Analysis of Clinical, Decongestion, and Safety Outcomes".Cardiovascular drugs and therapy · 2026Pooled it
- Combination Therapy of GLP-1 RA and SGLT2i in Patients with Established Heart Failure: A Systematic Review and Meta-Analysis of Observational Studies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Pooled it
- Patients' Experiences of Nurse-Led eHealth Interventions for Chronic Heart Failure: Qualitative Systematic Review and Meta-Synthesis.Journal of medical Internet research · 2026Pooled it
- Efficacy of plant extracts in heart failure patients: a systematic review and network meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- A systematic review of machine learning algorithms for mortality risk, readmission and phenotype prediction in patients with heart failure: exploring key data sources, input variables and outcomes.BMC medical informatics and decision making · 2026Pooled it
- Impact of androgen deprivation therapy and androgen receptor pathway inhibitors on cardiac structure and function evaluated by echocardiography in males with prostate cancer: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- HI-PLUS: design of a cluster-randomized trial evaluating structured case management with telemonitoring to improve quality of life in heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Trial
- External validation of the BAN-ADHF diuretic-resistance score in the DAPA-RESIST clinical trial.British journal of clinical pharmacology · 2026Trial
- Tailored Text Messaging Intervention to Improve Self-Care in Patients With Heart Failure (Text4HF): Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Kidney function and acid-base status as gatekeepers of natriuretic and diuretic responsiveness in chronic HF: insights from the DEA-HF clinical trial.European heart journal. Cardiovascular pharmacotherapy · 2026Trial
- Impact of canagliflozin on the cardiorenal effects of dietary sodium intake in type 2 diabetes: a post hoc analysis of the CREDENCE trial.Diabetologia · 2026Trial
- Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial.Circulation · 2026Trial
- Heart Failure Medication Withdrawal in Patients With Improved Cardiac Function After Atrial Fibrillation Ablation: The DEFINITION-AF Pilot Randomized Clinical Trial.JAMA network open · 2026Trial
- Determinants, risk score, and prognostic implications of left ventricular thrombus in ischemic cardiomyopathy assessed by cardiac magnetic resonance: a retrospective cohort study.Annals of medicine · 2026Article
- Article
- Predicting major adverse cardiovascular and cerebrovascular events in chronic heart failure: a machine learning study.Annals of medicine · 2026Article
- SGLT2 inhibitor prescription at discharge in very old adults with heart failure irrespective of diabetes status.International journal of cardiology. Heart & vasculature · 2026Article
- Economic evaluation of dapagliflozin added to standard therapy in chronic heart failure in Argentina: a cost-utility analysis.Lancet regional health. Americas · 2026Article
- Native QRS duration and outcomes in heart failure with mildly reduced ejection fraction: results from a large-scaled registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Precision-guided heart failure interventions: The expanding role of advanced cardiac imaging and artificial intelligence.American heart journal plus : cardiology research and practice · 2026Review
6,030 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
32 authors.
Theresa A McDonagh
Marco MetraORCID 0000-0001-6691-8568
Marianna Adamo
Roy S Gardner
Andreas Baumbach
Michael Böhm
Haran Burri
Javed Butler
Jelena Čelutkienė
Ovidiu Chioncel
John G F Cleland
Andrew J S Coats
Maria G Crespo-Leiro
Dimitrios Farmakis
Martine Gilard
Stephane Heymans
Arno W Hoes
Tiny Jaarsma
Ewa A Jankowska
Mitja Lainscak
Carolyn S P Lam
Alexander R Lyon
John J V McMurray
Alexandre Mebazaa
Richard Mindham
Claudio Muneretto
Massimo Francesco Piepoli
Susanna Price
Giuseppe M C Rosano
Frank Ruschitzka
Anne Kathrine Skibelund
ESC Scientific Document Group
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cardiac Resynchronization TherapyHeart FailureChronic DiseaseHumansStroke Volumeacute heart failureadvanced heart failurearrhythmiascardiac resynchronization therapycomorbiditiesdiagnosisejection fractionGuidelinesheart failurehospitalizationmechanical circulatory supportmultidisciplinary managementnatriuretic peptidesneuro-hormonal antagonistspharmacotherapytransplantation
Identifiers
PMID
34447992What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
NCT05580510ClinicalTrials.gov
NCT06442280ClinicalTrials.gov
NCT06706791ClinicalTrials.gov
NCT07482943ClinicalTrials.gov
NCT04592445ClinicalTrials.gov
NCT05141552ClinicalTrials.gov
and 48 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.