Evidence map›Paper›PMID 34452161›Full record

ReviewPharmaceutics2021

Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine.

Nolwenn Tessier, Fatma Moawad, Nada Amri, Davide Brambilla, Catherine Martel

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nolwenn TessierDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Fatma MoawadFaculty of Pharmacy, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Nada AmriDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Davide BrambillaFaculty of Pharmacy, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Catherine MartelDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease.

Indexed as

cardiovascular diseasesdrug delivery routelymphaticsnanotechnology

Identifiers

PMID34452161
PMCPMC8398144

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.