Evidence map›Paper›PMID 34452343›Full record

ArticleViruses2021

Yellow Fever Outbreak in Eastern Senegal, 2020-2021.

Moussa Moïse Diagne, Marie Henriette Dior Ndione, Alioune Gaye, Mamadou Aliou Barry, Diawo Diallo, Amadou Diallo, Lusajo L Mwakibete, Mamadou Diop, El Hadji Ndiaye, Vida Ahyong and 13 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Chikungunya outbreak in eastern Senegal, 2023.BMC infectious diseases · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
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  8. Insects · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Moussa Moïse DiagneVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0001-5461-5623
Marie Henriette Dior NdioneVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Alioune GayeZoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Mamadou Aliou BarryEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Diawo DialloZoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-7478-5248
Amadou DialloEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Lusajo L MwakibeteChan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Mamadou DiopEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
El Hadji NdiayeZoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-5007-0723
Vida AhyongChan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Babacar DioufZoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-8629-4278
Moufid MhamadiVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Cheikh Tidiane DiagneVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Fodé DanfakhaKedougou Medical Region, Ministry of Health, Kedougou 26005, Senegal.
Boly DiopPrevention Department, Ministry of Health, Dakar 220, Senegal.ORCID 0000-0001-5950-2628
Oumar FayeVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Cheikh LoucoubarEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-9582-4197
Gamou FallVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0001-5035-1325
Cristina M TatoChan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Amadou Alpha SallVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Scott C WeaverWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8016-8556
Mawlouth DialloZoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal.
Ousmane FayeVirology Department, Institut Pasteur de Dakar, Dakar 220, Senegal.

Funding

West African Center for Emerging Infectious DiseasesU01AI151801 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Robert W Cross, Scott C Weaver · 2020 to 2026
$10.1M
NIAID NIH HHS U01 AI151801NIH HHS 1U01AI151801-01
6 · The paper itself

Abstract

Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3'UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

Indexed as

AdolescentAdultAedesAmino Acid SequenceAnimalsChildDisease OutbreaksFemaleHumansMaleMosquito VectorsPhylogenySenegalSequence AlignmentViral ProteinsYellow FeverViral Proteins3′UTRarboviruseastern SenegalgenotypeKedougoulineagenext generation sequencingsylvatic lifecyclevirus isolationyellow fever virus

Identifiers

PMID34452343
PMCPMC8402698

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.