Evidence mapPaperPMID 34453049Full record

ArticleNature communications2021

Intravital imaging of islet Ca

Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Elina AkalestouSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.
Kinga SubaSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.
Livia Lopez-NoriegaSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.
Eleni GeorgiadouSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.ORCID http://orcid.org/0000-0003-4732-3678
Pauline ChabosseauSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.
Alasdair GallieCentral Biological Services (CBS) Hammersmith Hospital Campus, London, UK.
Asger WretlindSystems Medicine, Steno Diabetes Center, Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6083-5227
Cristina Legido-QuigleySystems Medicine, Steno Diabetes Center, Gentofte, Copenhagen, Denmark.
Isabelle LeclercSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK.
Victoria SalemSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK. v.salem@imperial.ac.uk.ORCID http://orcid.org/0000-0001-6463-7471
Guy A RutterSection of Cell Biology and Functional Genomics, Imperial College London, Hammersmith Hospital Campus, London, UK. g.rutter@imperial.ac.uk.ORCID http://orcid.org/0000-0001-6360-0343
Hammersmith Hospital · GBSteno Diabetes Centers · DKNanyang Technological University · SG

Funding

Medical Research Council MR/J0003042/1Medical Research Council MR/L020149/1Medical Research Council MR/L02036X/1Medical Research Council MR/N00275X/1Medical Research Council MR/R022259/1Medical Research Council MR/S025618/1Wellcome TrustWellcome Trust 212625/Z/18/Z
6 · The paper itself

Abstract

Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca

Indexed as

AnimalsBariatric SurgeryBlood GlucoseCalciumDiabetes MellitusFemaleGastrectomyGlucagon-Like Peptide 1HumansInsulinInsulin-Secreting CellsIntravital MicroscopyMaleMiceMice, Inbred C57BLStomachBlood GlucoseCalciumGlucagon-Like Peptide 1Insulin

Identifiers

PMID34453049
PMCPMC8397709
OpenAlexW3194195702

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.