ArticleBMC genomics2021
Comparative genomic analysis of a naturally born serpentized pig reveals putative mutations related to limb and bone development.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations.Journal of applied genetics · 2024Article
- An evolutionarily conserved mechanism that amplifies the effect of deleterious mutations in osteosarcoma.Molecular genetics and genomics : MGG · 2022Article
- SARS-CoV-2 competes with host mRNAs for efficient translation by maintaining the mutations favorable for translation initiation.Journal of applied genetics · 2022Article
- Cost-Efficiency Optimization Serves as a Conserved Mechanism that Promotes Osteosarcoma in Mammals.Journal of molecular evolution · 2022Article
- Compelling Evidence Suggesting the Codon Usage of SARS-CoV-2 Adapts to Human After the Split From RaTG13.Evolutionary bioinformatics online · 2021Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundIt is believed that natural selection acts on the phenotypical changes caused by mutations. Phenotypically, from fishes to amphibians to reptiles, the emergence of limbs greatly facilitates the landing of ancient vertebrates, but the causal mutations and evolutionary trajectory of this process remain unclear.
resultsWe serendipitously obtained a pig of limbless phenotype. Mutations specific to this handicapped pig were identified using genome re-sequencing and comparative genomic analysis. We narrowed down the causal mutations to particular chromosomes and even several candidate genes and sites, such like a mutation-containing codon in gene BMP7 (bone morphogenetic protein) which was conserved in mammals but variable in lower vertebrates.
conclusionsWe parsed the limbless-related mutations in the light of evolution. The limbless pig shows phenocopy of the clades before legs were evolved. Our findings might help deduce the emergence of limbs during vertebrate evolution and should be appealing to the broad community of human genetics and evolutionary biology.
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