Evidence map›Paper›PMID 34455814›Full record

ReviewHypertension (Dallas, Tex. : 1979)2021

Thu H Le

Open access · bronzeAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Unveiling the Role of GlutathioneACS pharmacology & translational science · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thu H LeDivision of Nephrology, Department of Medicine, University of Rochester Medical Center, NY.ORCID 0000-0002-6410-1623
University of Rochester Medical Center · US

Funding

GSTM1, APOL1, and their joint contribution to severity of hypertension and chronic kidney diseaseR01DK094907 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H., MYCHALECKYJ, JOSYF · 2012 to 2021
$1.7M
Safety, Feasibility and Efficacy of Sulforaphane in Chronic Kidney DiseaseR01DK128677 · NIDDK · UNIVERSITY OF ROCHESTER · PI LE, THU H. · 2021 to 2023
$884k
NIDDK NIH HHS R01 DK094907NIDDK NIH HHS R01 DK128677
6 · The paper itself

Abstract

In the United States, the prevalence of chronic kidney disease in adults is ≈14%. The mainstay of therapy for chronic kidney disease is angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, but many patients with chronic kidney disease still progress to end-stage kidney disease. Increased oxidative stress is a major molecular underpinning of chronic kidney disease progression. In humans, a common deletion variant of the glutathione-S-transferase μ-1 (

Indexed as

Precision MedicineAnimalsBrassicaceaeDietGlutathione TransferaseHumansHypertensionIsothiocyanatesKidney DiseasesNF-E2-Related Factor 2SulfoxidesGlutathione TransferaseIsothiocyanatesNFE2L2 protein, humanNF-E2-Related Factor 2sulforaphaneSulfoxidesglutathione transferasekidneyoxidative stressprecision medicineprevalence

Identifiers

PMID34455814
PMCPMC8429127
OpenAlexW3197712540

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.