Evidence map›Paper›PMID 34458660›Full record

ArticleToxicology communications2021

Unmet clinical laboratory need in patients hospitalized for acute poisoning from long-acting anticoagulant rodenticides.

Richard B van Breemen, John W Hafner, Daniel G Nosal, Douglas L Feinstein, Israel Rubinstein

Open access · goldAbstract read
In one paragraph

Article in Toxicology communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Non-adherence with long-term oral vitamin KToxicology communications · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Richard B van BreemenLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.
John W HafnerDepartment of Emergency Medicine, University of Illinois, Peoria, IL, USA.
Daniel G NosalLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Douglas L FeinsteinDepartment of Anesthesiology, University of Illinois, Chicago, IL, USA.
Israel RubinsteinJesse Brown VA Medical Center, Chicago, IL, USA.
Jesse Brown VA Medical Center · USOregon State University · USPeoria campus of the University of Illinois System · US

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI RICHARD D MINSHALL · 2017 to 2026
$13.6M
Intralipid: A novel frontline countermeasure for brodifacoum poisoningU01NS083457 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FEINSTEIN, DOUGLAS L. · 2013 to 2018
$3.6M
Optimization of Bile Sequestrants to Treat Superwarfarin PoisoningU01NS127746 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Douglas L. Feinstein · 2022 to 2026
$3.3M
Research Training in Natural Product Complementary and Integrative Health - Diversity Supplement to T32 Predoctoral Training GrantT32AT010131 · NCCIH · OREGON STATE UNIVERSITY · PI TAIFO MAHMUD, RICHARD B VAN BREEMEN · 2020 to 2026
$1.8M
BLR&D Research Career Scientist Award ApplicationIK6BX004852 · VA · JESSE BROWN VA MEDICAL CENTER · PI Douglas L. Feinstein · 2020 to 2026
–
BLRD VA IK6 BX004852NCCIH NIH HHS T32 AT010131NIEHS NIH HHS P30 ES027792NINDS NIH HHS U01 NS083457NINDS NIH HHS U01 NS127746
6 · The paper itself

Abstract

The importance of real-time, quantitative toxicology data available for physicians treating poisoned patients was illustrated during the 2018 outbreak in Illinois of severe coagulopathy caused by inhaling illicit synthetic cannabinoids products contaminated with commercially-available brodifacoum, difenacoum, and bromadiolone, three potent, long-acting anticoagulant rodenticides (LAARs). Identification and quantification of these life-threatening toxins in blood samples of hospitalized patients required toxicology testing with liquid chromatography-tandem mass spectrometry (LC-MS/MS) that was not available in clinical laboratories of hospitals at the time of the outbreak. This highly-sensitive, quantitative assay can provide critical information to guide patient care during and after hospitalization, including identification of offending LAARs, estimates of the ingested dose, and dosage and discontinuation of oral vitamin K

Indexed as

bleedingblood transfusionclotting factor concentrateINRsynthetic cannabinoidsvitamin K1

Identifiers

PMID34458660
PMCPMC8388241
OpenAlexW3166707909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.