ArticleJournal of the American Heart Association2021
Anxiety Disorders Are Associated With Coronary Endothelial Dysfunction in Women With Chest Pain and Nonobstructive Coronary Artery Disease.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Spontaneous coronary artery dissection in patients with prior psychophysical stress: a systematic review of case reports and case series.BMC cardiovascular disorders · 2024Pooled it
- Modifiable cardiovascular risk factors in people with polycystic ovarian syndrome (PCOS): Findings from the endocrine and mental health study.American journal of preventive cardiology · 2026Article
- Higher anxiety score in patients with non-obstructive coronary artery disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Article
- Symptom experience of women with ischemia and no obstructive coronary artery disease: A mixed-methods approach.American heart journal plus : cardiology research and practice · 2026Article
- Mental stress is associated with coronary endothelial dysfunction in women with chest pain and non-obstructive coronary artery disease.International journal of cardiology. Heart & vasculature · 2025Article
- Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome.Molecular psychiatry · 2025Article
- The Role of Chronic Stress in the Pathogenesis of Ischemic Heart Disease in Women.Comprehensive Physiology · 2025Review
- Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease.Science China. Life sciences · 2025Review
- The effects of 5-HT on vascular endothelial dysfunction in patients with panic disorder.Frontiers in cardiovascular medicine · 2025Review
- Article
- Novel diagnostic approaches and management of coronary microvascular dysfunction.American journal of preventive cardiology · 2024Article
- Alterations in Blood-Brain Barrier Integrity and Lateral Ventricle Differ in Rats Exposed to Space Radiation and Social Isolation.Life (Basel, Switzerland) · 2024Article
- Computed tomography myocardial perfusion imaging to detect myocardial ischemia in patients with anxiety and obstructive coronary heart disease post-exposure to mental stressors.Scientific reports · 2024Article
- Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan.Current atherosclerosis reports · 2024Review
- The effects of psychiatric disorders on the risk of chronic heart failure: a univariable and multivariable Mendelian randomization study.Frontiers in public health · 2024Article
- Dynamic myocardial perfusion computed tomography with mental stress test to detect changes in myocardial microcirculation in patients with anxiety and no obstructive coronary artery disease.European radiology · 2023Article
- Neuropsychiatric disorders in patients with heart failure: not to be ignored.Heart failure reviews · 2023Review
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Anxiety disorders are the most prevalent mental disorders and are an emerging risk factor for coronary artery disease and its complications. We determine the relationship between having a clinical diagnosis of an anxiety disorder and coronary endothelial dysfunction (CED) using invasive coronary reactivity testing across both sexes. Methods and Results Patients presenting with chest pain and nonobstructive coronary artery disease (stenosis <40%) at coronary angiography underwent an invasive assessment of CED. Patients were categorized as having a clinical diagnosis of an anxiety disorder at the time of coronary angiography by chart review. The frequency of CED was compared between patients with versus without an anxiety disorder and after stratifying patients by sex. Between 1992 and 2020, 1974 patients (mean age, 51.3 years; 66.2% women) underwent invasive coronary reactivity testing, of which 550 (27.9%) had a documented anxiety disorder at the time of angiography. There was a significantly higher proportion of patients with any type of CED in those with an anxiety disorder in all patients (343 [62.7%] versus 790 [56.4%];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.