ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- The relationship between white matter hyperintensity and gait in patients with cerebral small vessel disease.Frontiers in neurology · 2026Article
- Functional ultrasound as a quantitative approach for measuring functional hyperemia in aging models.NeuroImage · 2025Article
- Artificial intelligence-assisted oculo-gait measurements for cognitive impairment in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.Brain : a journal of neurology · 2024Article
- Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Baseline and Longitudinal MRI Markers Associated With 16-Year Mortality in Patients With Cerebral Small Vessel Disease.Neurology · 2024Article
- Structural Network Efficiency Predicts Conversion to Incident Parkinsonism in Patients With Cerebral Small Vessel Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Aberrant brain topological organization and granger causality connectivity in Parkinson's disease with impulse control disorders.Frontiers in aging neuroscience · 2024Article
- The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.Nutrients · 2023Review
- Cerebral small vessel disease: Recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Mining Correlation between Fluid Intelligence and Whole-brain Large Scale Structural Connectivity.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023Article
- Association between Changes in White Matter Microstructure and Cognitive Impairment in White Matter Lesions.Brain sciences · 2022Article
- Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate changes in gait performance over time and how these changes are associated with the decline in structural network efficiency and cognition in older patients with cerebral small vessel disease (SVD).
methodsIn a prospective, single-center cohort with 217 older participants with SVD, we performed 1.5T MRI scans, cognitive tests, and gait assessments evaluated by Timed UP and Go (TUG) test twice over 4 years. We reconstructed the white matter network for each subject based on diffusion tensor imaging tractography, followed by graph-theoretical analyses to compute the global efficiency. Conventional MRI markers for SVD, that is, white matter hyperintensity (WMH) volume, number of lacunes, and microbleeds, were assessed.
resultsBaseline global efficiency was not related to changes in gait performance, while decline in global efficiency over time was significantly associated with gait decline (ie, increase in TUG time), independent of conventional MRI markers for SVD. Neither baseline cognitive performance nor cognitive decline was associated with gait decline.
conclusionsWe found that disruption of the white matter structural network was associated with gait decline over time, while the effect of cognitive decline was not. This suggests that structural network disruption has an important role in explaining the pathophysiology of gait decline in older patients with SVD, independent of cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.