Evidence map›Paper›PMID 34465018›Full record

ArticlemBio2021

A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria.

Yiqiao Bao, Andrew A Verdegaal, Brent W Anderson, Natasha A Barry, Jing He, Xiang Gao, Andrew L Goodman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. NontoxigenicMicroorganisms · 2026
    Review
  2. Antagonism by the type VI secretion system ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Lessons from the model gut BacteroidalesJournal of bacteriology · 2025
    Review
  5. A nonenzymatic effector disruptsProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yiqiao BaoDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Andrew A VerdegaalDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Brent W AndersonDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Natasha A BarryDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Jing HeState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China.
Xiang GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China.
Andrew L GoodmanDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Yale University · USShandong University · CN

Funding

Causes and consequences of interpersonal microbial variationR35GM118159 · NIGMS · YALE UNIVERSITY · PI Andrew L Goodman · 2016 to 2026
$5.6M
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM118159
6 · The paper itself

Abstract

Human gut microbes exhibit a spectrum of cooperative and antagonistic interactions with their host and also with other microbes. The major

Indexed as

Host Microbial InteractionsAnimalsAnti-Bacterial AgentsBacterial ToxinsBacteriocinsBacteroides fragilisFemaleGastrointestinal MicrobiomeHumansIntestinesMaleMetabolic Networks and PathwaysMetalloendopeptidasesMiceMice, Inbred C57BLAnti-Bacterial AgentsBacterial ToxinsBacteriocinsBacteroides fragilis toxinMetalloendopeptidasesbacteriocinBacteroidesinterbacterial interactionmicrobiome

Identifiers

PMID34465018
PMCPMC8406203
OpenAlexW3197415927

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.