Evidence map›Paper›PMID 34465263›Full record

ArticlePharmaceutical biology2021

Long-term toxicological studies on the Chinese medicine 2036 Specialty-Qiangxin recipe in rats.

Andong Zhao, Yi Yang, Xiaohua Pan, Manhon Chung, Sa Cai, Yu Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andong ZhaoHealth Science Center, Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-2420-808X
Yi YangHealth Science Center, Shenzhen University, Shenzhen, China.
Xiaohua PanDepartment of Trauma and Orthopedics, The 2nd Affiliated Hospital of Shenzhen University, The Affiliated Baoan Hospital of Southern Medical University, Shenzhen, China.
Manhon ChungDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Sa CaiHealth Science Center, Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-4750-4674
Yu PanDepartment of Trauma and Orthopedics, The 2nd Affiliated Hospital of Shenzhen University, The Affiliated Baoan Hospital of Southern Medical University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe traditional medicine 2036 Specialty-Qiangxin recipe (2036S-QXR) has been widely used in China to improve cardiac function, prevent stroke, and strengthen the immune system. However, its long-term toxicity remains unknown.

objectiveThe present study evaluates the long-term toxicity of 2036S-QXR in rats. MATERIALS AND

methods2036S-QXR (0.6, 1.2, and 2.4 g/kg body weight per day) was orally administered for 26 weeks to Wistar rats, while the rats in the control group received distilled water. The effects on urinary, hematological, biochemical, and histopathological parameters were investigated during the study period.

resultsNo significant changes in all tested parameters were observed in the 0.6 and 1.2 g/kg groups, compared with the control group ( DISCUSSION AND

conclusionsThe present study shows that 2036S-QXR does not cause long-term toxicity, supporting its therapeutic use. To further determine the optimal doses, future studies should test more doses and include more animals in each group.

Indexed as

Toxicity TestsAnimalsDose-Response Relationship, DrugDrugs, Chinese HerbalFemaleMaleMedicine, Chinese TraditionalRatsRats, WistarTime FactorsDrugs, Chinese Herbalqiangxinadverse effectsGanoderma lucidum sporegrape seedsRhodiola roseaTraditional medicine

Identifiers

PMID34465263
PMCPMC8436967

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.