Evidence map›Paper›PMID 34465835›Full record

ArticleScientific reports2021

Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis.

Yoshifumi Amari, Satoshi Morimoto, Chikahito Suda, Takeshi Iida, Hidenobu Okuda, Takatomi Yurugi, Yasuo Oyama, Naoki Aoyama, Fumitaka Nakajima, Atsuhiro Ichihara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yoshifumi AmariDepartment of Nephrology, Moriguchi Keijinkai Hospital, Osaka, Japan.
Satoshi MorimotoDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. morimoto.satoshi@twmu.ac.jp.
Chikahito SudaDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Takeshi IidaDepartment of Nephrology, Moriguchi Keijinkai Hospital, Osaka, Japan.
Hidenobu OkudaDepartment of Nephrology, Moriguchi Keijinkai Hospital, Osaka, Japan.
Takatomi YurugiDepartment of Nephrology, Moriguchi Keijinkai Hospital, Osaka, Japan.
Yasuo OyamaDepartment of Nephrology and Dialysis, Neyagawa Keijinkai Clinic, Osaka, Japan.
Naoki AoyamaDepartment of Nephrology and Dialysis, Moriguchi Keijinkai Clinic, Osaka, Japan.
Fumitaka NakajimaDepartment of Nephrology and Dialysis, Kadoma Keijinkai Clinic, Osaka, Japan.
Atsuhiro IchiharaDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Tokyo Women's Medical University · JPTeine Keijinkai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR. The serum s(P)RR level is associated with arteriosclerosis, independent of other risk factors, in patients undergoing hemodialysis (HD). This study was conducted to investigate whether the s(P)RR level was associated with new-onset cardiovascular events or malignant diseases and poor prognosis in patients undergoing HD. Overall, 258 patients [70 (61-76) years, 146 males] undergoing maintenance HD were prospectively followed up for 60 months. We investigated the relationships between s(P)RR levels and new-onset cardiovascular events/ malignant diseases and mortality during the follow-up period using Cox proportional hazard analyses. The cumulative incidence of new-onset cardiovascular events (P = 0.009) and deaths (P < 0.001), but not of malignant diseases, was significantly greater in patients with higher serum s(P)RR level (≥ 29.8 ng/ml) than in those with lower s(P)RR level (< 29.8 ng/ml). A high serum s(P)RR level was independently correlated with cardiovascular mortality (95% CI 1.001-1.083, P = 0.046). The serum s(P)RR level was associated with cardiovascular events and mortality, thus qualifying as a biomarker for identifying patients requiring intensive care.

Indexed as

Renal DialysisAgedBiomarkersCardiovascular DiseasesFemaleHumansMaleMiddle AgedNeoplasmsPrognosisProrenin ReceptorProtein PrecursorsReceptors, Cell SurfaceRisk FactorsVacuolar Proton-Translocating ATPasesATP6AP2 protein, humanBiomarkersProrenin ReceptorProtein PrecursorsReceptors, Cell SurfaceVacuolar Proton-Translocating ATPases

Identifiers

PMID34465835
PMCPMC8408265
OpenAlexW3156879404

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.