Evidence map›Paper›PMID 34467755›Full record

ArticleACS infectious diseases2021

Docusate-Based Ionic Liquids of Anthelmintic Benzimidazoles Show Improved Pharmaceutical Processability, Lipid Solubility, and

Yogesh Sutar, Sophie R Fulton, Sagarkumar Paul, Sophie Altamirano, Susmit Mhatre, Hiwa Saeed, Pratikkumar Patel, Sudipta Mallick, Roopal Bhat, Vandana B Patravale and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Enhanced encapsulation and membrane retention ofInternational journal of pharmaceutics: X · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential.International journal of molecular sciences · 2023
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yogesh SutarDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.
Sophie R FultonDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Sagarkumar PaulDepartment of Pharmaceutical Sciences, Creighton University School of Pharmacy and Health Profession, 2200 California Plaza, Omaha, Nebraska 68710, United States.
Sophie AltamiranoDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Susmit MhatreDepartment of Pharmaceutical Sciences, Institute of Chemical Technology, N.P Marg, Matunga, Mumbai, Maharashtra 400011, India.
Hiwa SaeedDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.ORCID 0000-0002-5430-3942
Pratikkumar PatelDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.
Sudipta MallickDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.
Roopal BhatDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.
Vandana B PatravaleDepartment of Pharmaceutical Sciences, Institute of Chemical Technology, N.P Marg, Matunga, Mumbai, Maharashtra 400011, India.
Harsh ChauhanDepartment of Pharmaceutical Sciences, Creighton University School of Pharmacy and Health Profession, 2200 California Plaza, Omaha, Nebraska 68710, United States.
Kirsten NielsenDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Abhijit A DateDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.ORCID 0000-0001-6617-882X
University of Hawaii at Hilo · USUniversity of Minnesota · USCreighton University · USInstitute of Chemical Technology · INUniversity of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Youping Deng · 2012 to 2026
$60.3M
Training Research Educators in Minnesota (TREM) whilst increasing diversityK12GM119955 · NIGMS · UNIVERSITY OF MINNESOTA · PI David Irwin Greenstein, Julia Willett · 2017 to 2026
$6.5M
Impact of Cryptococcus Titan Cells on Pathogenesis.R01AI134636 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Kirsten Nielsen · 2018 to 2026
$4.6M
Genomic Research Capacity Building for Cryptococcosis Translational StudiesR01NS118538 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Joel Bazira, David Bisagaya Meya · 2020 to 2026
$3.4M
A link between mating pheromone sensing and virulence of Cryptococcus neoformansK22AI070152 · NIAID · UNIVERSITY OF MINNESOTA · PI NIELSEN, KIRSTEN · 2008 to 2009
$267k
NIAID NIH HHS K22 AI070152NIAID NIH HHS R01 AI134636NIGMS NIH HHS K12 GM119955NIGMS NIH HHS P20 GM103466NINDS NIH HHS R01 NS118538
6 · The paper itself

Abstract

As the existing therapeutic modalities for the treatment of cryptococcal meningitis (CM) have suboptimal efficacy, repurposing existing drugs for the treatment of CM is of great interest. The FDA-approved anthelmintic benzimidazoles, albendazole, mebendazole, and flubendazole, have demonstrated potent but variable

Indexed as

AnthelminticsCryptococcus neoformansIonic LiquidsPharmaceutical PreparationsBenzimidazolesDioctyl Sulfosuccinic AcidMolecular Docking SimulationSolubilityAnthelminticsBenzimidazolesDioctyl Sulfosuccinic AcidIonic LiquidsPharmaceutical PreparationsCapryol 90cryptococcosisdocusateDSCLabrasolpolymorphism

Identifiers

PMID34467755
PMCPMC8884109
OpenAlexW3197365879

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.