Evidence map›Paper›PMID 34470464›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

XB130 Deficiency Causes Congenital Hypothyroidism in Mice due to Disorganized Apical Membrane Structure and Function of Thyrocytes.

Yingchun Wang, Hiroki Shimizu, Yun-Yan Xiang, Junichi Sugihara, Wei-Yang Lu, Xiao-Hui Liao, Hae-Ra Cho, Hiroaki Toba, Xiao-Hui Bai, Sylvia L Asa and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Thyroid Hormone Synthesis Without Thyroglobulin.Thyroid : official journal of the American Thyroid Association · 2026
    Article
  2. Defective Thyroglobulin: Cell Biology of Disease.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yingchun WangLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Hiroki ShimizuLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Yun-Yan XiangLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Junichi SugiharaLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Wei-Yang LuDepartment of Physiology and Pharmacology, University of Western Ontario, London, Canada.
Xiao-Hui LiaoDepartment of Medicine and Chicago, Illinois, USA.
Hae-Ra ChoLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Hiroaki TobaLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Xiao-Hui BaiLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Sylvia L AsaDepartment of Pathology, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0001-8418-5054
Peter ArvanDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4007-8799
Samuel RefetoffDepartment of Medicine and Chicago, Illinois, USA.ORCID 0000-0003-0164-8231
Mingyao LiuLatner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.ORCID 0000-0002-9188-8417
University Health Network · CAUniversity of Illinois Chicago · USWestern University · CAUniversity of Michigan · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
Endoplasmic Reticulum stress and thyroid cell deathR01DK132017 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN · 2022 to 2026
$1.9M
CIHR MOP-119514CIHR MOP-31227CIHR MOP-42546NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R01 DK132017
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCongenital HypothyroidismIodineMiceMicrofilament ProteinsThyroid Epithelial CellsThyroid HormonesThyroxineAdaptor Proteins, Signal TransducingIodineMicrofilament ProteinsThyroid HormonesThyroxineXB130 protein, mouseadaptor proteincell polaritycongenital hypothyroidismfolliculogenesisthyroglobulin release and iodinationthyroid hormone synthesis and secretion

Identifiers

PMID34470464
PMCPMC8917886
OpenAlexW3197883125

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.