Trial reportSignal transduction and targeted therapy2021
Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Efficacy and safety of Yi'anning pills for stable angina pectoris in coronary heart disease with -blood and liver-kidney deficiency syndrome: a multicenter, randomized, double-blind, superiority clinical trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Trial
- Modular PheWAS reveals the therapeutic heterogeneity landscape of Danghong injection on stable angina pectoris.Molecular biomedicine · 2026Article
- Article
- Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren's syndrome and identifies PS(36:1) as a potential therapeutic target.Journal of translational medicine · 2025Article
- Efficacy and safety of Shenxiong-Xinmaikang Decoction in patients with stable angina pectoris: a real-world prospective observational study.Frontiers in pharmacology · 2025Article
- Genetic Commonalities Between Metabolic Syndrome and Rheumatic Diseases Through Disease Interactome Modules.Journal of cellular and molecular medicine · 2025Article
- Efficacy of danhong injection adjuvant therapy in patients with acute ischemic stroke: a real-world, multicenter, retrospective study.Frontiers in pharmacology · 2025Article
- Efficacy and safety of danshen class injections in the treatment of coronary heart disease: a network meta-analysis.Frontiers in pharmacology · 2024Review
- Discovery of Drug-Responsive Phenomic Alteration-Related Driver Genes in the Treatment of Coronary Heart Disease.Pharmacogenomics and personalized medicine · 2023Article
- Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.Bioengineering & translational medicine · 2023Article
- Metabolomics Profiles Reveal the Efficacy of Wuzhuyu Decoction on Patients with Chronic Non-Atrophic Gastritis.Drug design, development and therapy · 2023Article
- Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure.Molecular medicine (Cambridge, Mass.) · 2022Article
- Traditional Chinese medicine injections: where we are after 80-year development.Chinese medicine · 2022Review
- Toward better translation of clinical research evidence into rapid recommendations for traditional Chinese medicine interventions: A methodological framework.Integrative medicine research · 2022Review
- Discovering a Multi-Component Combination against Vascular Dementia from Danshen-Honghua Herbal Pair by Spectrum-Effect Relationship Analysis.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Cochrane systematic reviews on traditional Chinese medicine: What matters-the quantity or quality of evidence?Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022Article
- Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases.Frontiers in pharmacology · 2022Review
- Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids ofFrontiers in pharmacology · 2022Article
- SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse.Cell death and differentiation · 2021Article
Corrections and comments
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Authors and funding
80 authors at 20 institutions in 1 country.
Jun Liu *Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Dan-Dan Li *Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
Wei DongDepartment of Cardiology, Chinese PLA General Hospital, Beijing, China.
Yu-Qi LiuDepartment of Cardiology, Chinese PLA General Hospital, Beijing, China.
Yang WuDepartment of Cardiology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Da-Xuan TangDepartment of Cardiology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Fu-Chun ZhangDepartment of Geratology, Peking University Third Hospital, Beijing, China.
Meng QiuDepartment of Geratology, Peking University Third Hospital, Beijing, China.
Qi HuaDepartment of Cardiology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Jing-Yu HeDepartment of Cardiology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Jun LiDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Bai DuDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Ting-Hai DuDepartment of Cardiology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Lin-Lin NiuDepartment of Cardiology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Xue-Jun JiangDepartment of Cardiology, Wuhan University Renmin Hospital, Wuhan, Hubei, China.
Bo CuiDepartment of Cardiology, Wuhan University Renmin Hospital, Wuhan, Hubei, China.
Jiang-Bin ChenDepartment of Cardiology, Wuhan University Renmin Hospital, Wuhan, Hubei, China.
Yang-Gan WangDepartment of Cardiology, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
Hai-Rong WangDepartment of Cardiology, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
Qin YuAffiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Jing HeAffiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Yi-Lin MaoDepartment of Cardiology, Second Affiliated Hospital to Hunan University of Chinese Medicine, Changsha, Hunan, China.
Xiao-Fang BinDepartment of Cardiology, Second Affiliated Hospital to Hunan University of Chinese Medicine, Changsha, Hunan, China.
Yue DengDepartment of Cardiology, First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.
Yu-Dan TianDepartment of Cardiology, First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.
Qing-Hua HanDepartment of Cardiology, First Affiliated Hospital to Shanxi Medical University, Taiyuan, Shanxi, China.
Da-Jin LiuDepartment of Cardiology, First Affiliated Hospital to Shanxi Medical University, Taiyuan, Shanxi, China.
Li-Qin DuanDepartment of Cardiology, First Affiliated Hospital to Shanxi Medical University, Taiyuan, Shanxi, China.
Ming-Jun ZhaoDepartment of Cardiology, Affiliated Hospital of Shanxi University of Chinese Medicine, Xianyang, Shanxi, China.
Cui-Ying ZhangDepartment of Cardiology, Affiliated Hospital of Shanxi University of Chinese Medicine, Xianyang, Shanxi, China.
Hai-Ying DaiDepartment of Cardiology, Changsha Central Hospital, Changsha, Hunan, China.
Ze-Hua LiDepartment of Cardiology, Changsha Central Hospital, Changsha, Hunan, China.
Ying XiaoDepartment of Cardiology, Changsha Central Hospital, Changsha, Hunan, China.
You-Zhi HuDepartment of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China.
Xiao-Yu HuangDepartment of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China.
Kun XingDepartment of Cardiology, Shanxi Provincial People's Hospital, Xi'an, Shanxi, China.
Xin JiangDepartment of Cardiology, Shanxi Provincial People's Hospital, Xi'an, Shanxi, China.
Chao-Feng LiuDepartment of Cardiology, Shanxi Province Hospital of Traditional Chinese Medicine, Xi'an, Shanxi, China.
Jing AnDepartment of Cardiology, Shanxi Province Hospital of Traditional Chinese Medicine, Xi'an, Shanxi, China.
Feng-Chun LiDepartment of Cardiology, Xi'an City Hospital of Traditional Chinese Medicine, Xi'an, Shanxi, China.
Tao TaoDepartment of Cardiology, Xi'an City Hospital of Traditional Chinese Medicine, Xi'an, Shanxi, China.
Jin-Fa JiangDepartment of Cardiology, Shanghai Tongji Hospital, Shanghai, China.
Ying YangDepartment of Cardiology, Shanghai Tongji Hospital, Shanghai, China.
Yao-Rong DongDepartment of Cardiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
Lei ZhangDepartment of Cardiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
Guang FuDepartment of Cardiology, The First Hospital of Changsha, Changsha, Hunan, China.
Ying LiDepartment of Cardiology, The First Hospital of Changsha, Changsha, Hunan, China.
Shu-Wei HuangDepartment of Cardiology, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Li-Ping DouDepartment of Cardiology, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Lan-Jun SunDepartment of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Zengchan Dao, Tianjin, China.
Ying-Qiang ZhaoDepartment of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Zengchan Dao, Tianjin, China.
Jie LiDepartment of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Zengchan Dao, Tianjin, China.
Yun XiaDepartment of Chinese medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Jun LiuDepartment of Chinese medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Fan LiuDepartment of Cardiology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China.
Wen-Jin HeDepartment of Cardiology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China.
Ying LiDepartment of Cardiology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China.
Jian-Cong TanDepartment of Cardiology, Third People's Hospital of Chongqing, Chongqing, China.
Yang LinDepartment of Cardiology, Third People's Hospital of Chongqing, Chongqing, China.
Ya-Bin ZhouDepartment of Cardiology, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Jian-Fei YangDepartment of Cardiology, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Guo-Qing MaDepartment of Cardiology, Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Hui-Jun ChenDepartment of Cardiology, Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
He-Ping LiuDepartment of Cardiology, Jilin Province People's Hospital, Changchun, Jilin, China.
Zong-Wu LiuDepartment of Cardiology, Jilin Province People's Hospital, Changchun, Jilin, China.
Jian-Xiong LiuDepartment of Cardiology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Xiao-Jia LuoDepartment of Cardiology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Xiao-Hong BinDepartment of Cardiology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Ya-Nan YuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Hai-Xia DangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Bing LiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Fei TengBeijing Genomics Institute (Shenzhen), Shenzhen, Guangdong, China.ORCID 0000-0003-4913-7094
Wang-Min QiaoBeijing Genomics Institute (Shenzhen), Shenzhen, Guangdong, China.
Xiao-Long ZhuBeijing Genomics Institute (Shenzhen), Shenzhen, Guangdong, China.
Bing-Wei ChenSchool of Public Health, Southeast University, Nanjing, Jiangsu, China.
Qi-Guang ChenSchool of Public Health, Southeast University, Nanjing, Jiangsu, China.
Chun-Ti ShenChangzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Yong-Yan WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. wangyongyan2010@sina.cn.
Yun-Dai ChenDepartment of Cardiology, Chinese PLA General Hospital, Beijing, China. cyundai@medmail.com.cn.
Zhong WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. zhonw@vip.sina.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNShanxi Medical University · CNChinese PLA General Hospital · CNFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine · CNTianjin University of Traditional Chinese Medicine · CNBGI Group (China) · CNChangsha Central Hospital · CNChengdu Second People's Hospital · CNThe First Hospital of Changsha · CNWuhan University · CNXuan Wu Hospital of the Capital Medical University · CNBeijing University of Chinese Medicine · CNFirst Affiliated Hospital of Henan University · CNFirst People's Hospital of Chongqing · CNHubei Provincial Hospital of Traditional Chinese Medicine · CNPeking University · CNPeople 's Hospital of Jilin Province · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNShanghai Traditional Chinese Medicine Hospital · CNShanxi Province Hospital of Traditional Chinese Medicine · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart disease. Here, in an adaptive, 31-center, randomized, double-blind trial involving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI), a kind of polypharmacological drug with high quality control, or placebo (0.9% saline), with 76-day following-up, we firstly confirmed that DHI could increase the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire (ΔSAQ-AF ≥ 20) (12.78% at Day 30, 95% confidence interval [CI] 5.86-19.71%, P = 0.0003, 13.82% at Day 60, 95% CI 6.82-20.82%, P = 0.0001 and 8.95% at Day 90, 95% CI 2.06-15.85%, P = 0.01). We also found that there were no significant differences in new-onset major vascular events (P = 0.8502) and serious adverse events (P = 0.9105) between DHI and placebo. After performing the RNA sequencing in 62 selected patients, we developed a systemic modular approach to identify differentially expressed modules (DEMs) of DHI with the Z
Indexed as
AdolescentAdultAgedAngina, StableCardiovascular AgentsDouble-Blind MethodDrugs, Chinese HerbalFemaleGene Expression RegulationHumansInjectionsMaleMiddle AgedTreatment OutcomeYoung AdultCardiovascular AgentsdanhongDrugs, Chinese Herbal
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.