Evidence map›Paper›PMID 34472718›Full record

ReviewImmunity, inflammation and disease2021

Role of neutrophils in acute viral infection.

Yuan Ma, Yue Zhang, Liuluan Zhu

Open access · goldAbstract readReview
In one paragraph

Review in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 95 citations in OpenAlex.

  1. Trial
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  4. Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  18. Molecular detection and occurrence of contagious ecthyma in goat.Tropical animal health and production · 2025
    Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yuan MaInstitute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing, China.
Yue ZhangBeijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Liuluan ZhuInstitute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing, China.ORCID 0000-0001-9078-2576
Capital Medical University · CNPeking University · CN

Funding

Beijing Municipal Administration of Hospitals' Youth Programme QML20201801Beijing Municipal Commission of Education of Science and Technology Project No. KM202010025006Beijing Talents Foundation 2018000021223ZK27National Natural Science Foundation of China 81671940National Natural Science Foundation of China 81871586
6 · The paper itself

Abstract

Neutrophils play multiple roles in acute viral infections. They restrict viral replication and diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and the release of neutrophil extracellular traps, as well as, activate the adaptive immune response. However, the overactivation of neutrophils may cause tissue damage and lead to poor outcomes. Additionally, some characteristics and functions of neutrophils, such as cell number, lifespan, and antiviral capability, can be influenced while eliminating viruses. This review provides a general description of the protective and pathological roles of neutrophils in acute viral infection.

Indexed as

Extracellular TrapsVirus DiseasesAdaptive ImmunityHumansNeutrophilsPhagocytosisantiviral immunityCOVID-19neutrophilneutrophil extracellular trap

Identifiers

PMID34472718
PMCPMC8589350
OpenAlexW3196822288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.