Evidence map›Paper›PMID 34475432›Full record

ArticleScientific reports2021

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.

Irene Cimino, Debra Rimmington, Y C Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G Kay, Samuel Virtue, Brian Y H Lam, Luca Fagnocchi, Marcella K L Ma and 10 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. MidbrainbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

Irene CiminoMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Debra RimmingtonMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Y C Loraine TungMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Katherine LawlerUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust‑MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Pierre LarraufieMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Richard G KayMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Samuel VirtueMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Brian Y H LamMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Luca FagnocchiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.
Marcella K L MaMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Vladimir SaudekMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Ilona ZvetkovaMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Antonio Vidal-PuigMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Giles S H YeoMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
I Sadaf FarooqiUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust‑MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
J Andrew PospisilikDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.
Fiona M GribbleMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Frank ReimannMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Stephen O'RahillyMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
Anthony P CollMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK. apc36@cam.ac.uk.
Wellcome/MRC Institute of Metabolic Science · GBWellcome Trust · GBVan Andel Institute · US

Funding

British Heart Foundation RG/12/13/29853British Heart Foundation RG/18/7/33636Medical Research Council G0400192Medical Research Council G0802051Medical Research Council MC_G0802535Medical Research Council MC_UU_00014/1Medical Research Council MC_UU_00014/2Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12012/2Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Wellcome TrustWellcome Trust 207462/Z/17/Z
6 · The paper itself

Abstract

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat

Indexed as

AnimalsBiomarkersBody WeightDiet, High-FatEatingEnergy MetabolismFemaleGene Expression ProfilingMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsObesityBiomarkersMembrane ProteinsNerve Tissue ProteinsNnat protein, mouse

Identifiers

PMID34475432
PMCPMC8413370
OpenAlexW3196716655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.