ArticleNature aging2021
The physical frailty syndrome as a transition from homeostatic symphony to cacophony.
Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06974006 (Integrated Monitoring for Independent Living in Rural Settings), which is not on this map. Cited by 303 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Monitoring for Independent Living in Rural Settings
Who cites it
303 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of air pollution and increased risk of frailty.Age and ageing · 2025Pooled it
- DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.PloS one · 2026Trial
- Trial
- "Brain-IT": Exergame training with biofeedback breathing in neurocognitive disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- Translating and testing feasibility and reliability of the Clinical Frailty Scale for assessing older adults in Greenland.International journal of circumpolar health · 2026Article
- Time matters: circadian genetics and the molecular logic of human health and disease.Nature reviews. Genetics · 2026Review
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Dynamic frailty exposure and cognitive aging trajectories: A multicohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis.Arthritis care & research · 2026Article
- Frailty in Parkinson's disease: time to integrate it into treatment decision-making?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Effect of bodyweight interval training on frailty status in older adults: a randomized controlled trial.European geriatric medicine · 2026Article
- Individualised but Specific Exercise Training Improves Physiologic Reserve and Reduces Frailty in Older Adults with Chronic Lymphocytic Leukaemia: A 12-Week Pragmatic Randomised Controlled Trial.medRxiv : the preprint server for health sciences · 2026Article
- The association between hospital frailty risk score and adverse inpatient outcomes in older adults with colorectal cancer.British journal of cancer · 2026Article
- From Optimism to Opportunity: New Perspectives on the Osteological Paradox.American journal of biological anthropology · 2026Review
- Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multidimensional physiological impairments are associated with frailty and survival in older patients with cancer.Journal of translational internal medicine · 2026Article
- Latent profiles and network dynamics of psychological frailty in older adults: a computational simulation study.BMC geriatrics · 2026Article
- Assessing effects of RAI, GNRI, and anemia on morbidity and mortality in elderly neurosurgery patients with major complications.Neurosurgical review · 2026Article
- Associations of IL-17 and TGF-β1 with physical frailty in older adults.GeroScience · 2026Article
- Development and validation of a multidimensional physical function-focused frailty at risk index for early detection of functional decline in community-dwelling older adults.Scientific reports · 2026Article
243 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophysiology underpinning the clinical presentation of physical frailty as a phenotype of a clinical syndrome that is distinct from the cumulative-deficit-based frailty index. We focus on integrating the converging evidence on the conceptualization of physical frailty as a state, largely independent of chronic diseases, that emerges when the dysregulation of multiple interconnected physiological and biological systems crosses a threshold to critical dysfunction, severely compromising homeostasis. Our exegesis posits that the physiology underlying frailty is a critically dysregulated complex dynamical system. This conceptual framework implies that interventions such as physical activity that have multisystem effects are more promising to remedy frailty than interventions targeted at replenishing single systems. We then consider how this framework can drive future research to further understanding, prevention and treatment of frailty, which will likely preserve health and resilience in aging populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.